益肾清利化瘀汤对急性肾盂肾炎大鼠病理改变的影响  

Influence of Shen Qing Li Hua Yu Tang on Patholosic changes of acute Pyelonephritis in rat

作　　者：龚学忠[1] 孟秋[2] 杨践[2] 何立群[2] 郑平东[2] 

机构地区：[1]上海中医药大学,2001级博士生上海200032 [2]上海市曙光医院,上海200022

出　　处：《深圳中西医结合杂志》2003年第5期280-282,共3页Shenzhen Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的　探讨益肾清利化瘀汤治疗尿路感染的实验室依据。方法　建立急性肾盂肾炎大鼠模型 ,以左氧氟沙星为对照 ,观察益肾清利化瘀汤对该模型的肾脏病理学改变的影响。结果　与模型组相比 ,益肾清利化瘀汤组和左氧氟沙星组肾盂炎症较轻 ,表现在肾脏纵切面仅见有粘膜充血 ,第 7、15天肾盂粘膜病理和间质区较少的灶性淋巴细胞浸润 ;而模型组可见到肾包膜紧张和肾盂扩张 ,以及光镜下明显的灶性淋巴细胞浸润。Objective To explore the experimental basis of Yi Shen Qing Li Hua Yu Tang (YSQLHY)in treating UIT.Methods Experimental,ascending acute pyelonephritis was produced in mice to observe YSQLHY′s influence in the pathologic changs of kidneys,with Levofloxacin Lactate Tablets(LeLT) as contrast.Results The pathologic changs of kidneys in YSQLHY group and LeLT group were lighter when compared with Model group,including the lighter lymphocyte soaking in renal interstitium.Conclusion YSQLHY should partly alleviate APN mice′s pathologic changs of kidney.

关 键 词：益肾清利化瘀汤 急性肾孟肾炎 病理学 大鼠 

分 类 号：R692.7[医药卫生—泌尿科学] R-332[医药卫生—外科学]