内皮型一氧化氮合酶基因G894T变异与超重和高血压的关系  

Relationship between mutation of exon G894T of endothelial nitric oxide synthase gene and overweight to essential hypertension

作　　者：贾崇奇[1] 赵仲堂[1] 王立华 郝风荣[1] 冯月秋[1] 王束玫[1] 徐晓菲[1] 贾存显[1] 

机构地区：[1]山东大学公共卫生学院流行病学教研室,济南250012 [2]济南钢铁职工总医院二区分院

出　　处：《中华预防医学杂志》2003年第5期365-367,共3页Chinese Journal of Preventive Medicine

摘　　要：目的　探讨内皮型一氧化氮合酶 (eNOS)基因第 7外显子G894T变异与超重在高血压患病中的意义。方法　在人群中筛检出未经药物系统治疗的 116例高血压患者及 136名血压正常者为研究对象 ;运用PCR 限制性片段长度多态性检测G894T变异 ;用相加模型分析G894T变异与超重之间的交互作用 ;用人群归因危险度百分比 (PAR % )反映人群中的病因分值。结果　G894T变异与超重对高血压患病具有正交互作用 ;归因交互效应为 1 99;归因交互效应百分比为 30 76 % ;纯因子间归因交互效应百分比为 36 38%。用多元logistic回归分析调整年龄、性别、吸烟指数及饮酒指数后 ,G894T变异与超重对高血压患病仍具有正交互作用。调整上述混杂因素后 ,归因交互效应为 2 85 ;归因交互效应百分比为 39 97% ;纯因子间归因交互效应百分比为 4 6 4 9%。在给定条件下计算的PAR %约为 15 %。结论　eNOS基因第 7外显子G894T变异与超重之间的交互作用在该研究人群高血压患病中具有重要意义 ;在仅仅对具有G894T变异与超重同时存在的部分人群中控制超重可明显降低一般人群高血压的患病率。Objective To explore the relationship between the 7th exon G894T mutation of endothelial nitric oxide synthase (eNOS) gene and overweight in patients with essential hypertension. Methods Totally, 116 patients with essential hypertension taking no medcications and 136 normotensives were selected from a steel workers as study subjects. Polymerase chain reaction and restriction fragment length polymorphism were performed to detect nutation of the 7th exon G894T. Additive model was used to analyze interaction between G894T mutation and overweight on hypertension. Population attributable risk percent (PAR%) for them, etiologic fraction, was applied to their contribution to hypertension. Results There was a positive interaction between G894T mutation and overweight on essential hypertension, with an index of interaction of 1.99 and attributable interaction percent of 30.76%. Their pure attributable interaction percent was 36.38%. Multiple logistic regression analysis showed that there still was positive interaction between G894T mutation and overweight on essential hypertension, adjusted for age, sex, smoking and alcohol drinking. Index of their attributable interaction was 2.85, with attributable interaction percent of 39.97%, also adjusted for the above-mentioned factors. Their pure attributable interaction percent was 46.49% and PAR% was estamated as about 15% under certain condition. Conclusions Interaction between nutation of the 7th exon G894T of eNOS gene and overweight played an important role in essential hypertension of the studied population. Control of body weight in the population with both G894T mutation and overweight could markedly decrease their risk of hypertension.

关 键 词：内皮型一氧化氮合酶 基因G894T变异 超重 高血压 发病机制 

分 类 号：R544.1[医药卫生—心血管疾病] R589.2[医药卫生—内科学]