家兔血清中黄芩苷的薄层扫描法测定及药动学参数  

Determination of Baicalin in Rabbits Serum by TLC Scanning and Its Pharmacokinetic Parameters

作　　者：赵建荣[1] 巩俊卿[2] 张述禹[3] 白喜翠[3] 王伟[3] 

机构地区：[1]内蒙古医学院第一附属医院肾内科,内蒙古呼和浩特010059 [2]武警内蒙古总队医院内一科,内蒙古呼和浩特010031 [3]内蒙古医学院药学系,内蒙古呼和浩特010059

出　　处：《中国医药工业杂志》2003年第11期569-571,共3页Chinese Journal of Pharmaceuticals

摘　　要：采用薄层扫描法测定家兔血清中的黄芩甙及在兔体内的药物动力学参数。结果显示血清药物浓度在 0 .5～2 5 μg/ ml范围内线性关系良好 ,体内药物动力学呈开放性二室模型。并通过回收率试验确定了方法的准确性。A TLC scanning method for determination of baicalin in rabbits serum and its pharmacokinetic parameters was established. The calibration curve was linear in the range of 0.5～25 μg/ml( r=0.9942 ). The accuracy of the method was checked by recoveries. The pharmacokinetic study showed that it accorded with opening two compartment model.

关 键 词：黄芩甙 药物动力学 薄层扫描 测定 

分 类 号：R969.1[医药卫生—药理学] O657.73[医药卫生—药学]