螺旋霉素高产株的推理选育和工业生产  

Rational Selection of Streptomycesambofaciensand Industrial Higher Production of Spiramycin

作　　者：宋友礼[1] 屠小平 胡巍[1] 黄根娣[1] 

机构地区：[1]上海医药工业研究院,上海200040 [2]浙江绍兴制药厂,浙江绍兴312000

出　　处：《中国医药工业杂志》2003年第11期552-554,共3页Chinese Journal of Pharmaceuticals

摘　　要：产二素链霉菌 SIPI 90 0 4经自发或诱发的突变和推理选育 ,得到若干耐药性变种。第六代一株变种 10 - 2 9,产生螺旋霉素比原始菌株 SIPI90 0 4增产约 6倍。该变种应用于工业生产 (30 m3发酵罐 ) ,发酵效价、总单位和指数三项指标比原来生产菌株 F- 16分别提高 2 6 .1%、33.3%和 2 6 .8%。The spontaneous or induced mutation and rational selection of Streptomyces ambofaciens SIPI90 0 4 ,a series of high- yield mutantstrains for drug- tolerance were obtained.The1 0 - 2 9mutantstrain of the sixth generation produced an approximately six- fold higher level of spiramycin than the original strain SIPI 90 0 4 .Industrial production of 1 0 - 2 9mutant strain was performed in 30 m3 fermentor.The po- tency,total units and index of fermentation increased by2 6.1 % ,33.3% and2 6.8% respectively as com- pared with the former strain F- 1 6.

关 键 词：产二素链霉菌 螺旋霉素 推理育种 耐药性变种 

分 类 号：TQ456[化学工程—农药化工]