大鼠主动脉球囊成形术后尾加压素II受体的变化  

The alteration of urotensin-II receptors in rat aorta after balloon angioplasty injury

作　　者：夏春芳[1] 徐少平[2] 张勇刚[1] 杨军[1] 霍勇[1] 庞永正[1] 唐朝枢[1] 

机构地区：[1]北京大学第一医院心血管研究所,北京100034 [2]北京军区总医院心内科,北京100700

出　　处：《中国病理生理杂志》2001年第7期593-597,共5页Chinese Journal of Pathophysiology

基　　金：国家九五医学攻关项目 (No .96 - 90 6 0 2 - 0 7);国家自然科学基金资助项目 (No .39730 2 2 0 )

摘　　要：目的 :观察大鼠主动脉球囊成形术后尾加压素II (UII)受体特征的变化及血管对UII收缩效应的改变。方法 :测定大鼠主动脉球囊损伤后 [12 5I]-UII配体结合及血管张力。结果 :球囊成形术后 3d、2 1d时 ,血管对UII的反应性增强 (P <0 0 5 ) ,主动脉UII受体最大结合 (Bmax)较对照组分别高 44 %及 36 % [(35 0 3± 2 41)pmol/gproteinand (33 2 6± 2 40 )pmol/gproteinvs(2 4 37± 3 2 0 )pmol/gprotein ,P <0 0 1],受体与配体解离常数 (Kd)无显著差异 (P >0 0 5 )。结论 :血管球囊损伤后UII受体发生上调 ,受体密度增加 ,血管对UII的反应性增强 ,表明UII可能在血管成形术后再狭窄过程中发挥重要作用。AIM: To observe the alteration of urotensin II (UII) receptors and contractile response to UII in rat aorta after balloon angioplasty injury. METHODS: The plasma membrane isolated from balloon injured aorta was used to study the binding of [ 125 I]-UII to the membrane and the contractile potency of UII on rat aorta was assayed. RESULTS: In contrast to the normal aorta, the contractile potency to UII enhanced in balloon injury artery and the calculated maximal number of specific binding sites (Bmax) was increased about 44% and 36% respectively in rat artery after balloon injury 3 and 21 days ( P< 0.01). CONCLUSION: The density of UII receptors and the contractile response to UII had changed after balloon angioplasty injury. It was proposed that UII might play an important role in the intervention of restenosis after angioplasty. [

关 键 词：大鼠 主动脉球囊成形术 术后 尾加压素Ⅱ受体 主动脉球囊损伤 

分 类 号：R654.3[医药卫生—外科学]