传染性法氏囊病疫苗免疫种鸡后子代雏鸡的免疫学变化  

Immunological changes of chicks from hens vaccinated with infectious bursal disease(IBD) vaccine

作　　者：郑世民[1] 葛铭 胡守萍[1] 甄荣[1] 高雪丽[1] 王笑梅 王秀荣 

机构地区：[1]东北农业大学动物医学院,黑龙江哈尔滨150030 [2]哈尔滨兽医研究所

出　　处：《东北农业大学学报》2001年第4期352-359,共8页Journal of Northeast Agricultural University

摘　　要：应用现代免疫学新技术对传染性法氏囊病 (IBD)疫苗免疫种鸡后 ,其子代雏鸡外周血液和免疫器官组织的免疫学变化进行了动态研究。结果发现 :传染性法氏囊病疫苗免疫种鸡后 ,其子代雏鸡外周血液 T、B细胞数量和 Ig G,Ig M,Ig A含量及免疫器官组织的 T细胞、Ig G,Ig M,Ig A抗体生成细胞数量均不同程度地高于未免疫的相应对照雏鸡 ,表明 IBD疫苗免疫母鸡后 ,子代雏鸡外周血液和免疫器官组织的体液免疫和细胞免疫功能明显增强。而传染性法氏囊病超强毒攻击子代雏鸡后 ,未免疫的子代雏鸡 ,外周血液和免疫器官组织的上述各项指标均明显低于疫苗免疫的子代雏鸡 ,这与 IBDV感染雏鸡后 ,其免疫器官组织严重损害 ,淋巴细胞变性坏死等有关 。This experiment was undertaken dynamic study of immunological changes in the peripheral blood,immune organs and tissues of chicks from hens vaccinated with infection bursal disease(IBD) vaccine using the new technique of modern immunology.The results were as follows:The number of immunoglobin(Ig)G,IgM,IgA antibody-producing cells and T cell of thymus,bursal Fabricius and spleen in off springs of hens significantly increased in comparsion with those of non-immunized controls.Theas results showed that funtion of humoral immune and cellular immune of the peripheral blood and immune organs of chicks from hens vaccinated with IBD vaccine could be enhanced.Post challenged of filial generation chicks from hens with very virulent infectious bursal disease virus(vvIBDV),the every item,the above-montioned,in the peripheral blood,immune organs and tissuse of chicks from hens no-vaccinated with IBD vaccine was lowered than those of vaccinated-challenged chicks.This matter has immune organs and tissues of chicks infected with vvIBDV to be injured seriously.$$$$

关 键 词：传染性法氏囊病 疫苗 免疫种鸡 后子代雏鸡 免疫学变化 

分 类 号：S858.31[农业科学—临床兽医学]