地塞米松对预防术后硬膜外吗啡镇痛引起恶心呕吐疗效评价  

Effect of dexamethasone on preventing postoperative nausea and vomiting related to epidural morphine analgesia

作　　者：侯瑞礁[1] 周为民[1] 沈伯雄[1] 

机构地区：[1]上海第二医科大学附属宝钢医院麻醉科,上海201900

出　　处：《海南医学》2001年第12期13-14,共2页Hainan Medical Journal

摘　　要：目的　评估静注地塞米松 10mg对术后硬膜外吗啡镇痛引起恶心呕吐的效应。方法　 12 0例术后行硬膜外吗啡镇痛病人 ,术毕随机静注地塞米松 10mg(地米组n =60 )或生理盐水 2ml(对照组n =60 )。结果　术后 48小时内恶心呕吐发生率 :地米组 (5 4例病人中有 8例 ) 14 81% ,对照组 (5 8例病人中有 11例 ) 18 96%。两组发生率比较P>0 .0 5。结论　静注地塞米松对预防术后硬膜外吗啡镇痛引起恶心呕吐的作用不明显 。Objective To estimate the effect of dexamethasone (Dex) intravenous injection on preventing postoperative nausea and vomiting related toepidural morphine analgesia.Methods 120 patients requring postoperative analgesia with epidural morphine were randomized into two groups.Dexamethasone 10mg(Dex group n=60) or saline (control group n=60) was administed i.v.at the end of the surgery.Results The total incidence of postoperative nausea and vomiting 14.81% in Dex group druing 48 hours after surgery and it was 18.96%in control group(P>0.05).Conclusion The effect of Dexamethasone intruvenous injection on preventing postoperative nausea and vomiting related to epidural morphine analgesia is not obvious,but it is effective to treat postoperative nausea and vomiting.

关 键 词：地塞米松 术后 硬膜外镇痛经恶心 呕吐 疗效评价 吗啡 

分 类 号：R977.1[医药卫生—药品] R619[医药卫生—药学]