食管鳞状细胞癌组织中细胞胀亡及微血管密度检测  

Detection of oncosis and microvessel density in esophageal squamous cell carcinoma

作　　者：赵高峰[1] 僧靖静[1] 鲁显浩 高冬玲[3] 田川[1] 王善磊[1] 刘文超 付明倜[1] 马继红[1] 屈清荣[1] 赵松[1] 张云汉[3] 

机构地区：[1]郑州大学第一附属医院外科,郑州450052 [2]原阳县人民医院外科,原阳453500 [3]郑州大学第一附属医院病理科,郑州450052 [4]郸城县人民医院外科,郸城477150

出　　处：《郑州大学学报（医学版）》2003年第6期851-854,共4页Journal of Zhengzhou University(Medical Sciences)

基　　金：河南省杰出青年科学基金资助项目 0 3 12 0 0 2 3 0 0

摘　　要：目的 :检测人食管鳞状细胞癌组织中细胞胀亡及微血管密度 (MVD)。方法 :利用透射电镜和免疫组织化学技术 ,对 6 0例手术切除的食管癌组织进行细胞胀亡和MVD检测 ,分析胀亡指数 (OI)与肿瘤MVD、临床病理分期、分化的关系。结果 :食管鳞状细胞癌组织中存在胀亡细胞 ;N0 期癌组织中OI高于N1 期 (P <0 .0 5 ) ;随分化程度的升高 ,OI升高 (P <0 .0 0 5 ) ;MVD高表达组OI高于低表达组 (P <0 .0 0 1 ) ,OI与T分期无关。结论 :食管鳞状细胞癌组织中存在胀亡细胞 。Aim: To detect the oncosis and microvessel density (MVD) in tissues of esophageal squamous cell carcinoma. Methods: By using transmission electron microscope and immunohistochemical technique, the occurrence of oncosis and MVD in 60 cases of esophageal carcinoma was tested. The interrelationship between oncosis index (OI), MVD, pathological stages, and differential grades was analyzed. Results:Oncosis was detected in the esophageal carcinoma. OI was higher in tissues at N 0 stage than that at N 1 stage ( P <0.05). OI increased with the increase of differentiation grades ( P < 0.005). OI was higher in the MVD low-expressed group than that in the MVD high-expressed group ( P <0.001). OI did not correlate with T stages. Conclusion: Oncosis occurs in esophageal squamous cell carcinoma, and it might play a certain role in the biological behavior of esophageal carcinoma.

关 键 词：食管肿瘤 鳞状细胞癌 细胞胀亡 微血管密度 

分 类 号：R765.3[医药卫生—耳鼻咽喉科]