鼠移植肺组织中细胞胀亡、SOD及MDA检测  

Detection of oncosis,SOD and MDA in pulmonary tissue after pulmonary transplantation in rats

作　　者：赵高峰[1] 僧靖静[1] 陈照阳[2] 卫战文 王善磊[1] 田川[1] 梅永城[4] 赵松[1] 马继红[1] 高冬玲[5] 陈奎生[5] 张云汉[5] 

机构地区：[1]郑州大学第一附属医院外科,郑州450052 [2]淮滨县人民医院外科,淮滨464400 [3]孟州市中医院外科,孟州454750 [4]郑州大学,98级医学生郑州450052 [5]郑州大学第一附属医院病理科,郑州450052

出　　处：《郑州大学学报（医学版）》2003年第6期867-870,共4页Journal of Zhengzhou University(Medical Sciences)

基　　金：河南省杰出青年科学基金资助项目 0 3 12 0 0 2 3 0 0

摘　　要：目的 :探讨移植肺中是否存在胀亡细胞及其可能的临床意义。方法 :对 30例大白鼠进行左侧单肺移植 ,利用透射电镜和病理学技术 ,检测移植肺、健侧肺及空白对照肺组织胀亡细胞 ,MDA及SOD活力。结果 :移植肺较健侧肺内存在更多胀亡细胞 ,主要是Ⅱ型上皮细胞发生胀亡 ,空白对照肺组织内较少有细胞胀亡。结论Aim: To detect cell oncosis,SOD and MDA in lung tissue after pulmonary transplantation. Methods:Pulmonary transplantation was carried out with 30 rats. Cell oncosis, MDA, and SOD activity were detected by using transmission electron microscope and pathological techniques. Results: More oncosis cells presented in transplanted lung compared with the control healthy lung, and oncosis affected Ⅱ-type cells more commonly. Rare oncosis was observed in the normal control lung tissue. Conclusion: Cell oncosis may play an important role in the pathogenesis and development of pulmonary transplantation rejection.

关 键 词：肺移植 细胞胀亡 排斥反应 大鼠 

分 类 号：R654.2[医药卫生—外科学]