妊娠早期反复自发性流产与患者免疫因素的关系  

The Relation Between Recurrent Spontaneous Abortion and Immune Factors During Early Period of Pregnancy

作　　者：郭玉霞[1] 赵晓岚[2] 张建华[1] 

机构地区：[1]暨南大学医学院第二附属医院妇产科,广东深圳518020 [2]西安交通大学第二医院遗传研究室,陕西西安710004

出　　处：《医学临床研究》2003年第10期760-761,共2页Journal of Clinical Research

摘　　要：目的探讨妊娠早期反复自发性流产 (RSA)与抗心磷脂抗体 (ACA) ,抗子宫内膜抗体 (AEA)和抗精子抗体 (ASA)之间的关系。方法采用ELISA法检测 338例反复自发性流产患者 (研究组 )血清ACA ,EMA以及ASA。选择 6 9例无流产史并已分娩的妇女作为对照组。结果研究组ACA ,AEA和ASA阳性检出率 (2 6 .92 %、2 1.0 1%、30 .18%)与对照组 (8.70 %、7.2 0 %、11.5 9%)相比 ,差异有显著性意义 (P <0 .0 1)。结论RSA与ACA、AEA和ASA之间有密切关系 ,可作为不明原因流产的常规检查项目。ObjectivesTo explore the relation between recurrent spontaneous abortion (RSA) and several immune factors, including anticardiolipin antibody (ACA),antiendometrial antibody (AEA) and antisperm antibody (ASA) during early period of pregnancy.MethodsEnzyme-linked immunosorbent assay (ELISA) was carried out to detect serum levels of ACA,AEA and ASA in 338 women with RSA (research group); while 69 women without history of miscarriage and delivered live-birth served as control group.ResultsThe positive rates of ACA,AEA and ASA in research group (26.92%、21.01%、30.18%)were significantly higher than those in the control group(8.70%、7.20%、11.59%), respectively(P<0.01).ConclusionIt is suggested that serum levels of ACA,AEA and ASA were closely correlated with RSA during early period of pregnancy, so they can be scheduled as items for routine examination of abortions with unknown causes.

关 键 词：妊娠早期 反复自发性流产 免疫因素 抗心磷脂抗体 抗子宫内膜抗体 抗精子抗体 

分 类 号：R714.21[医药卫生—妇产科学]