EGF及EGFR在口腔复发性阿弗他溃疡中的表达特征及意义  

EGF AND EGFR EXPRESSION IN RECURRENT APHTHOUS ULCER AND ITS SIGNIFICANCE

作　　者：孙鹏[1] 张建强[1] 刘斌[1] 闫颖[1] 付小兵[1] 

机构地区：[1]解放军第304医院

出　　处：《解放军医学杂志》2003年第11期1005-1007,共3页Medical Journal of Chinese People's Liberation Army

基　　金：国家重大基础研究规划资助项目 (编号G1 9990 542 0 4 );国家杰出青年科学基金(编号 3952 50 2 4 );国家自然科学基金重点项目 (编号 30 2 30 370 )资助课题

摘　　要：目的　探讨表皮细胞生长因子 (EGF)及表皮细胞生长因子受体 (EGFR)在口腔复发性阿弗他溃疡组织 (RAU)中的表达特征及生物学意义。方法　应用免疫组化技术检测EGF及EGFR在RAU中表达和分布的变化规律。结果　EGF的蛋白颗粒在正常口腔黏膜中主要分布于基底层细胞和棘层细胞中 ,阳性表达出现在胞浆中 ,RAU组织中EGF表达明显减少 (P <0 0 5 ) ;EGFR在正常黏膜和RAU中表达均较弱 ,阳性表达位于细胞膜和胞浆中 ,在正常黏膜中表达主要位于基底细胞层中 ,在RAU中该蛋白表达明显减少 (P <0 0 5 )。结论　RAU中EGF和EGFR表达受到抑制 。Objective To explore the change in EGF(epidermal growth factor)and EGFR(epidermal growth factor receptor)expression in recurrent aphthous ulcer. Methods The expression intensity and distribution of EGF and EGFR were examined with immunohistochemistry method in 8 cases of recurrent aphthous ulcer and 7 specimens of normal oral mucosa. Results In normal oral mucosa, immuno staining of EGF was mainly localized in basal layer cells and prickle layer cells. The expression intensity of EGF was higher in normal oral mucosa than that in aphthous ulcer ( P <0 05), while the distribution was similar in tissues from either source. In all samples, the expression in EGFR was weak. The difference in EGFR expression between aphthous and normal mucosa was significant ( P <0 05). Conclusion These findings indicate that the protein expression of EGF and EGFR is decreased in aphthous ulcer which may be one of the mechanisms involved in RAU formation

关 键 词：表皮生长因子 表皮生长因子受体 口腔溃疡 免疫组织化学 

分 类 号：R178.5[医药卫生—妇幼卫生保健]