头孢菌素C钠盐最佳制备工艺探讨  

Study on the Technics to Produce Cephalosporin C Sodium

作　　者：李丽娅[1] 梁方君[1] 

机构地区：[1]黑龙江大学职业技术学院,哈尔滨150080

出　　处：《黑龙江医药》2003年第6期515-516,共2页Heilongjiang Medicine journal

摘　　要：为了探讨制备头孢菌素 C 钠盐的最佳工艺,采用溶媒结晶法和喷雾干燥法分别制备头孢菌素 C 钠盐。结果是,溶媒结晶法制备的头孢菌素 C 钠盐含量和透光率均值分别为84.03%和95.90%,分别与喷雾干燥法比较,P<0.05。溶媒结晶法合格率为100%,而喷雾干燥法合格率仅为20%。结论溶媒结晶法制备头孢菌素 C 钠盐的方法优于喷雾干燥法。Objective To investigate the best technics to produce cephalosporin C sodium Method using menstruum crystallization and spray drying methods to rpoducecephalosporin C sodium and comparin the products by the two methods Results The content of cephalosporin C sodium and transmittance of the products by menstruum crystalliszation method were 84.03% and 95.90% respectively,which are significantly different from the ones produced by spray drying method(P<0.05).The qualified rate of cephalosporin C sodium by menstruum crystallization method was 100%,but the qualified rate of cephalosporin C sodium by spray drying method was just 20%.Conclusion To produce cephalosporin C sodium,menstruum crystallization method is much better than spray drying method.

关 键 词：头孢菌素C钠盐 制备工艺 溶媒结晶法 喷雾干燥法 

分 类 号：TQ465.1[化学工程—制药化工]