二乙基二巯基氨基甲酸钠对大鼠皮肤成纤维细胞增殖及胶原蛋白合成的影响  

EFFECTS OF SODIUM DIETHYLDITHIO CARBAMATE ON PROLIFERATION OF SKIN FIBROBLAST AND SYNTHASIS OF COLLAGEN IN RATS

作　　者：裴仁九[1] 齐荔红[1] 刘云[1] 刘锡钧[1] 

机构地区：[1]中国人民解放军南京军区福州总医院临床药理科,福州350025

出　　处：《解放军药学学报》1999年第3期20-22,共3页Pharmaceutical Journal of Chinese People's Liberation Army

摘　　要：目的：研究二乙基二巯基氨基甲酸钠（ＤＴＣ） 对大鼠皮肤成纤维细胞增殖及胶原蛋白合成的影响。方法：采用［３Ｈ］ － 胸腺嘧啶核苷和［３Ｈ］ － 脯氨酸掺入法，分别测定成纤维细胞增殖和胶原蛋白合成。结果：ＤＴＣ低剂量时促进成纤维细胞增殖，高剂量时抑制成纤维细胞的增殖和胶原蛋白合成。结论：ＤＴＣ能抑制胶原蛋白的合成。AIM Effects of sodium diethyldithio carbamate (DTC)on proliferation of skin fibroblast and synthasis of collagen were studied in rats.METHODS [ 3H]-thymidine and [ 3H]-proline uptake was adopted to measure fibroblast proliferation and collagen synthesis respectively.RESULTS The data indicated that DTC could enhance fibroblast proliferation at the low dose and suppress fibroblast proliferation and collagen synthesis at the high doses.CONCLUSION DTC could inhibite collagen synthesis.It has biphasic effect on fibroblast proliferation.

关 键 词：二乙基二巯基氨基甲酸钠 DTC 大鼠 皮肤 成纤维细胞 细胞增殖 胶原蛋白 免疫活性 

分 类 号：R96[医药卫生—药理学] R-332[医药卫生—药学]