不同浓度的氮酮对鼻宁滴鼻剂透皮吸收的影响  

EFFECTS OF AZONE OF VARIED CONCENTRATIONS ON TRANSDERMAL ABSORPTION OF BINING-DROP SOLUFION

作　　者：宋玉华[1] 杜光焰[1] 隋广志[1] 王海峰[1] 

机构地区：[1]中国人民解放军第203医院,齐齐哈尔161000

出　　处：《解放军药学学报》1999年第5期53-54,F003,共3页Pharmaceutical Journal of Chinese People's Liberation Army

摘　　要：目的：为鼻宁滴鼻剂选择适宜浓度的透皮促进剂。方法：采用紫外分光光度法，测定加不同浓度氮酮的鼻宁滴鼻剂对小白鼠离体皮肤透皮吸收的影响。结果：加１％ 、２．５％ 氮酮的鼻宁滴鼻液，其透皮吸收百分率较高。结论：选择加１ ％ 、２ ．５ ％ 氮酮为透皮促进剂，制剂结果满意。AIM To select a suitable concentration of transdermal enhancer for Bining-Drop.METHODS The effects of different concentrations of azone on the transdermal absorption of mouse isolated skin were investigated by UV.RESUSLT Bining-Drop that contained 1 percent and 2.5 percent of azone had good absorption.CONCLUSION 1 percent and 2.5 percent of azone was regar as transdermal enhancers.

关 键 词：浓度 氮酮 鼻宁滴鼻剂 透皮吸收剂 紫外分光光度法 

分 类 号：R987[医药卫生—药品]