脑血氧饱和度的近红外光谱测量技术及其在超重条件下的应用  

Measurement of Cerebral Blood Oxygen Saturation with Near Infrared Spectroscopy and Its Application in Hypergravity.

作　　者：孙佳石[1] 佟文革[2] 陈默然[2] 肖志伟[2] 

机构地区：[1]中国科学院长春光学精密机械与物理研究所,吉林长春130022 [2]第四军医大学吉林军医学院,吉林吉林130013

出　　处：《航天医学与医学工程》2003年第5期371-373,共3页Space Medicine & Medical Engineering

基　　金：20 0 1年全军医药卫生科研基金课题 "十五"面上项目 ( 0 1MA2 0 2 )

摘　　要：目的用近红外光谱技术对加速度作用后 (超重条件下 )的大鼠进行脑血氧饱和度 ( %SaO2 )的无损监测。方法制作头部不同程度缺血缺氧模型 ,抽血测量其血氧饱和度 ,并计算出与正常组之间的差值。同时测定出在 85 0nm和 760nm波长处缺血缺氧模型的光谱吸收强度 ,计算出与正常组之间的差值 ,并绘制出两者之间的关系曲线。根据关系曲线 ,通过用近红外光谱仪监测高 +Gz和推拉动作后的光谱吸收强度 ,计算出与 0Gz组差值 ,推测出加速度作用后脑血氧饱和度。结果由关系曲线推测出加速度作用后 ,大鼠脑血氧饱和度降低 ;推拉动作后 ,脑血氧饱和度降低更为明显。结论根据关系曲线 。Objective To measure the oxygen saturation of blood in rat′s brain non invasively after acceleration with near infrared spectroscopy technique. Method A serious of model about different ischemia and hypoxia of head, measured oxygen saturation by phlebotomize were made, and the difference with normal group was obtained.Its absorption intensity was measured and a curve showing the difference between the normal value was drawn.Acoording to the curve,cerebral blood oxygen saturation after acceleration was calculated with the measured absorption intensity after high +Gz or push pull maneuver by near infrared spectroscopy. Result Compared high Gz and push pull effect group with 0 Gz group, the content of ox hemoglobin reduced, in opposition the deox hemoglobin increased. the greater the difference, the lower the content of oxygen saturation of blood. Conclusion Oxygen saturation of blood in the rat′s brain can be obtained non invasively with near infrared spectroscopy.

关 键 词：血氧定量法 近红外光谱技术 加速度 推拉动作 

分 类 号：R852.21[医药卫生—航空、航天与航海医学] R318.6[医药卫生—临床医学]