单纯性肾病综合征患儿血T细胞亚群和免疫球蛋白改变及二者关系的探讨  

The Changes of T Cells Subpopulations and Immunoglobulin and Their Relationship in Children Patients with Simple Nephrotic Syndrome.

作　　者：张秋业[1] 董增义[1] 杨美玉[1] 董淑兰[1] 杨秀亭 

机构地区：[1]青岛医学院附属医院儿科 [2]山东省昌乐县人民医院儿科

出　　处：《实用儿科临床杂志》1992年第6期290-292,共3页Journal of Applied Clinical Pediatrics

摘　　要：研究目的 探讨单纯性肾病综合征患儿血T细胞亚群和免疫球蛋白的改变及二者关系。 研究设计 病例对照研究。 患者和参与者 单纯性肾病患儿39例,分为初发组和复发组(6例患儿初发和复发时均检测),初发组28例,男19例,女9例,年龄2～10岁,复发组20例,男12例,女8例,年龄3～13岁;对照组35名健康儿童,男21例,女14例,年龄2～13岁。 处理方法 用OKT系列单克隆抗体间接免疫荧光法检测T细胞亚群,用常规单相琼脂免疫扩散法检测血清Ig。 结果和结论 单纯性肾病患儿血CD^+_3和CD^+_4细胞无变化,CD^+_8和CD^+_(10)细胞明显增多,CD^+_4/CD^+_3比值明显低于对照组,初发和复发病例间无差异。85.3％患儿血 IgG水平下降,29.4％患儿血IgM水平升高。CD^+_4/CD^+_2细胞比值与血清IgG水平呈显著正相关,与IgM水平呈明显负相关。Objective To search for the changes of T cells subpopulations and immunoglobulin and their relation-ship in children patients with simple nephrotic syndrome. Design Case-control research. Patients aud Participants 39 patients with simple nephrotic syndrome were divided into two groups:the incipient group and relapse group (6 cases were determined at the incipient and relapse time) .Thereare 28 patients in incipient group, 19 males and 9 females, at the age of 2 to 10 years old. There are20 patients in relapse group, 12 males and 8 females, at the age of 3 to 13 years old. There are 35health children in control group, 21 males and 14 females, 2～13 years old. Interventions T cells subpopulations were determined by indirect immunofluorescence of OKT linesmonoclonal antibodies. The serum IgG was determined by routine simple agar immunodiffusion tests. Results and Conclusions The CD_3^+ and CD_4^+ cells are of no change in the children patients withsimple nephrotic syndrome, and the CD_8^+ and CD_(10)^+ cells are obviously increased, the Values of CD_4^+/CD_8^+ are obviously lower than those in the control qroup, there are no difference between the incipientand relapse groups. The levels of serum IgG were decreased in the 85.3% children patients, IgM were inc-reased in 29.4% of that. The values of CD_4^+/CD_8^+ have positive correlation and negative correlationwith the levels of serum IgG and IgM respectively.

关 键 词：肾病综合征 儿童 免疫球蛋白 

分 类 号：R726.92[医药卫生—儿科]