反溶剂重结晶法制备硫酸沙丁胺醇颗粒  

Preparation of ultrafine particles of salbutamol sulfate by anti-solvent precipitation

作　　者：马静[1] 王玉红[1] 陈建峰[1] 甄崇礼 

机构地区：[1]北京化工大学教育部超重力工程研究中心,北京100029 [2]新加坡纳米材料科技公司,新加坡139944

出　　处：《北京化工大学学报（自然科学版）》2003年第6期6-9,共4页Journal of Beijing University of Chemical Technology(Natural Science Edition)

基　　金：国家自然科学基金 ( 2 0 14 6 0 0 2 );国家"86 3"项目资助 ( 2 0 0 1AA2 180 6 1)

摘　　要：实验采用反溶剂重结晶法对硫酸沙丁胺醇进行超细化。将乙醇、异丙醇、丙酮作为反溶剂进行了对比实验 ,最后选定丙酮作为该体系的反溶剂 ,并且确定了最佳反溶剂和溶液的体积比为 10∶1。结果证明 ,体系的过饱和度ΔC越大重结晶所得到的颗粒就越小 ,采用反加法、低温、高搅拌速度能够增大体系的过饱和度 ,得到 30 0nm的针状颗粒产品。Ultrafine particles of salbutamol sulfate were produced by anti solvent precipitation. The optimal ratio of volume of anti solvent to salbutamol sulfate solution was 10∶1, in which acetone was selected as the anti solvent. The experimental results showed that the particle size became smaller with the increasing of the supersaturation (Δ C )of the solution, so the ultrafine particles of salbutamol sulfate of 300?nm can be produced by adding the solution to the anti solvent, especially in a high stirring speed and a low crystallization temperature.

关 键 词：硫酸沙丁胺醇 反溶剂 重结晶 超细粒子 

分 类 号：TQ463.23[化学工程—制药化工]