苏木抗癌有效成分对HL-60细胞的增殖抑制  

THE LEHIBITION OF HL-60 PROLIF ERATION BY ACTIVITY OF EXTRACT FROM CAESCALPININA SAPPAN L.

作　　者：乔丽娟[1] 徐建国[1] 马克荣[1] 

机构地区：[1]山西省肿瘤研究所,太原030013

出　　处：《海南医学》2001年第3期55-55,共1页Hainan Medical Journal

摘　　要：目的 :研究苏木 (CAE)抗癌有效成分 (化合物 )对 HL-6 0细胞的增殖抑制作用 ,并与化疗药物环磷酰胺(CP)的增殖抑制比较。方法 :采用 3 H-TDRBack man L S 5 0 0 0 CE液闪仪检测。结果 :苏木抗癌有效成分对 HL -6 0细胞的增殖抑制率显著 ,并在 (0 .40 -12 .8u g/ml) j呈剂量依赖性抑制 HL-6 0细胞 (r=0 .94,P<0 .0 0 1)。结论 :苏木抗癌有效成分对 HL-6 0细胞增殖抑制率显著 ,并优于 CP;Objective To observe the inhibition of HL-60 Proliferation by activity of extract from Caescalpinina sappan L.(CAE),and compare with Cyclophosphamide(CP).Method Cell inhibitory effect was assessed by 3 H-TDR Backman LS 5000CE.Results The inhibition rate of CAE-B was obvious and the proliferation of HL-60 cells was inhibited by CAE-B in a dose-dependent manner (r=0.94 P<0.001).Conculusion The inhibition of HL-60 Proliferation by CAE-B is singificantly higer than that CP.The CAE-B maybe become antitumor drugs.

关 键 词：苏木 抗癌有效成分 HL-60细胞 细胞增殖抑制 环磷酰胺 

分 类 号：R282.71[医药卫生—中药学]