Studies on the Effects of Steroid Hormone Contraceptives on Lipid, Lipoprotein and Apolipoprotein Metabolism in Chinese Women  

作　　者：杨培娟 宋思 杨秋英 桂幼伦 贺昌海 

出　　处：《Journal of Reproduction and Contraception》2000年第4期194-203,共10页生殖与避孕（英文版）

摘　　要：Objective To explore the effects of steroid hormone contraceptives (SHCs), such as Mercilon, Chinese No. 1 pill, Post coital pill, Mesigyna, and Cyclofem, on lipid metabolism in Chinese women during the last decade Materials & Methods A total of 122 healthy volunteers who requested contraception were recruited in the study and one of the above mentioned SHCs was administered.Fasting serum samples were taken from each subject before, during and after treatments. Triglycerides (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL c), low density lipoprotein cholesterol (LDL c), Apolipoprotein A I, A II and B were measured. The changes in the ratios of TC/HDL c, Apo A I/Apo B were also observed. Results Although the levels of lipid were either increased or decreased by any one of the 5 contraceptives, these changes recovered after withdrawal of the drug administration. No significant changes were detected in the ratios of TC/HDL c, Apo A I/Apo B during treatments. Conclusion The results suggest that there is no obvious impact on lipid profile induced by any of the 5 contraceptives within one year. The induced effects on lipid metabolism could be reduced by alternate use of 2 contraceptives with different biological activities.Objective To explore the effects of steroid hormone contraceptives (SHCs), such as Mercilon, Chinese No. 1 pill, Post coital pill, Mesigyna, and Cyclofem, on lipid metabolism in Chinese women during the last decade Materials & Methods A total of 122 healthy volunteers who requested contraception were recruited in the study and one of the above mentioned SHCs was administered.Fasting serum samples were taken from each subject before, during and after treatments. Triglycerides (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL c), low density lipoprotein cholesterol (LDL c), Apolipoprotein A I, A II and B were measured. The changes in the ratios of TC/HDL c, Apo A I/Apo B were also observed. Results Although the levels of lipid were either increased or decreased by any one of the 5 contraceptives, these changes recovered after withdrawal of the drug administration. No significant changes were detected in the ratios of TC/HDL c, Apo A I/Apo B during treatments. Conclusion The results suggest that there is no obvious impact on lipid profile induced by any of the 5 contraceptives within one year. The induced effects on lipid metabolism could be reduced by alternate use of 2 contraceptives with different biological activities.

关 键 词：DESOGESTREL LEVONORGESTREL NORETHISTERONE MEDROXYPROGESTERONE lipid metabolism 

分 类 号：R169.41[医药卫生—公共卫生与预防医学]