复聪片对老年大鼠蜗内神经结构影响的实验研究  

The Effect of Fucong Tablets on the Neural Elements in Cochleae of Aged Rats

作　　者：徐绍勤[1] 刘佳运[1] 彭斌[1] 吴宏 

机构地区：[1]湖南中医学院附二院耳鼻咽喉科,长沙410005

出　　处：《中国中西医结合耳鼻咽喉科杂志》2001年第1期6-8,共3页Chinese Journal of Otorhinolaryngology in Integrative Medicine

基　　金：国家新药研究基金!(94-95-32)

摘　　要：目的探讨复聪片防治老年性聋的机制。方法以老年大鼠疆孔内神经纤维和螺旋神经节为观察指 标。结果发现复聪片能有效支持上述蜗内神经结构。结果提示蜗内神经结构的退变可能是老年性聋的主要病 理基础。复聪片支持蜗内神经结构可能基于如下途径：①促进神经生长因子与其受体的结合。②通过保护毛细胞， 间接促进神经生长因子的产生。Objective To explore the therapeutic mechanism of Fucong Tablets on the presbycusis, Methods The nerve fibers in habenula perforta and spiral ganglion of aged rats were obsered in this project. Results Fucong Tablets could effectively support the neural element. Conclusion the research suggested that degeneration of neural elements in cochleae should be one of the major reasons for presbycusis. The maintenance of the neural elements should be related with the effects of Fucong Tablets as following: Promoting the nerve growth factor (NGF) to combine with its receptor. Protecting hair cell to produce indirectly neuraltrophin.

关 键 词：复聪片 大鼠 老年性聋 耳蜗 神经结构 药理作用 神经纤维 螺旋神经节 神经生长因子 

分 类 号：R285.5[医药卫生—中药学]