茶芎挥发油β~1环糊精包合物的制备工艺研究  

Study on the Inclusion Compound of Volatile Oil of Ligusticum with Hydroxypropyl-β-cyclodextrin

作　　者：姚松林[1] 胡铁山[2] 韩修林[1] 张凌[1] 蔡小刚[1] 黄亮[1] 

机构地区：[1]江西中医学院药学系,南昌330006 [2]江西中医学院附属医院药剂科,南昌330006

出　　处：《江西中医学院学报》2002年第2期24-25,28,共3页Journal of Jiangxi College of Traditional Chinese Medicine

基　　金：江西省自然科学基金资助项目 (No .9940 0 5 3 )

摘　　要：目的 :研究 β 环糊精包合茶芎挥发油的最佳工艺条件。方法 :采用饱和溶液搅拌法制备包合物 ,应用红外分光光度仪对包合物做了定性鉴别 ,并用正交试验法探讨制备包合物的最佳工艺条件。结果表明 :A3 B2 C2 D1为最佳包合工艺条件 ,即 :温度 6 0℃ ,搅拌时间 1.5小时 ,挥发油与 β 环糊精之比为 0 .8mL∶4 g ,β 环糊精与水之比为 1g∶2 0mL。结论 :此工艺简单、稳定 ,包合率和产率均好 ,适于工业化生产。Objective:To study the best way of preparing ligusticum with Hydroxypropyl β cyclodextrin.Method:the inclusion compound of ligusticum with Hydroxypropyl β cyclodextrin by aqueous solution stirring method.The inclusion compound of ligusticum with Hydroxypropyl β cyclodextrin was confirmed by IR spectroscopy,the best way of preparing ligusticum with Hydroxypropyl β cyclodextrin was studied by orthogonal experiment design.Results:The best result of preparing is A 3B 2C 2D 1,i.e.temperature:60 ℃,stirring time:1.5h,the ratio between Volatile Oil and Hydroxypropyl β cyclodextrin is 0.8 mL∶4 g.Conclusion:This preparation way is simple ,stable and suitable for factory manufacture.

关 键 词：茶芎挥发油 β—环糊精 包合物 制备工艺 正交试验法 红外分光光度仪 

分 类 号：TQ461[化学工程—制药化工]