中国汉族人群极低密度脂蛋白受体基因多态性与血脂水平的相关性研究  

Correlation Between CGG Triplet Repeat Polymorphism of VLDL-R gene and Blood Lipid Level in Chinese Han Population

作　　者：邵华[1] 左武[1] 李艳[1] 廖声荣[1] 张晓炜[1] 王宗和[1] 

机构地区：[1]武汉大学人民医院检验科,邮政编码武汉430060

出　　处：《微循环学杂志》2003年第4期42-44,共3页Chinese Journal of Microcirculation

摘　　要：目的 :对中国汉族人群极低密度脂蛋白受体 (VLDL R )基因CGG重复序列多态性与血脂水平及心脑血管病的相关性进行研究。方法 :检测湖北地区 75例冠心病 (CHD)、65例动脉粥样硬化性脑梗死 (ABI)和 160例正常人CGG重复序列 ,并分析各组血脂水平。结果 :共检出CGG重复次数为 5、8、9、11的 4种等位基因及 5 /5、5 /8、8/8、8/9、9/9、5 /9、8/11、5 /11等 8种基因型。CHD组与对照组、ABI组与对照组比较 ,VLDL R等位基因频率以及基因型频率分布无统计学差异 (P >0 .0 5 )。在CHD组和ABI组中 ,五个亚组间TC、TG、HDL -C、LDL -C、ApoAⅠ、ApoB及Lp(a)水平均无显著性差异 (P >0 .0 5 )。结论 :VLDL R基因多态性与人群中的血脂水平无关联 ,与心脑血管病 (CCVD)也没有关联。Objective: To investigate the distribution pattern of the CGG triplet of VLDL R gene in Chinese Han nationality and its relation with blood lipid level.Method: In Hubei region, there were including 75 cases with coronary heart disease (CHD), 65 cases with atherosclerotic brain infarct (ABI), and 160 healthy controls were studied.Results: 4 alleles and 8 gene types were found.There were no statistically significant differences ( P >0.05) in VLDL R gene allele and genotype frequencies between CHD and normal controls,also ABI and normal controls.When the subjects were divided into 5 subgroups according to VLDL R genotype, the differences among the subgroups were not statistically significant ( P >0.05).Conclusion: VLDL R gene polymorphism does not obvious influence on lipid metabolism and CCVD.

关 键 词：中国 汉族人群 极低密度脂蛋白受体 基因多态性 血脂 相关性 跨膜蛋白 心脑血管病 

分 类 号：Q26[生物学—细胞生物学]