先天性巨细胞病毒感染对婴幼儿的影响  

EFFECT OF CONGENTTAL HUMAN CYTOMEGALOVIRUS ESFECTION ON INFANTS

作　　者：李红梅[1] 张巍[1] 马雅玲[1] 孙慧红[1] 刘敬[1] 任春慧[1] 

机构地区：[1]北京妇产医院北京妇幼保健院NICU,100026

出　　处：《新生儿科杂志》2003年第5期210-212,206,共4页The Journal of Neonatology

摘　　要：为探讨先天性巨细胞病毒(CMV)感染对婴幼儿的影响,采用瞬态诱发性耳声发射(TEOAE)对65例先天性CMV感染儿及82例非感染儿于新生儿期进行听力筛查,并于生后6个月至4岁进行听力及智力随访。感染组发育商落后8例,对照组仅1例,二组差异显著。感染组新生儿期、随访时分别有7例9耳、9例11耳未通过TEOAE听力测试,对照组均为1例1耳未通过,未通过率感染组明显高于对照组。新生儿期、随访时双耳反应能量感染组明显低于对照组。14例进行了脑干听觉诱发电位(ABR)检测,感染组9例17耳听力异常,对照组1例1耳听力异常。提示先天性CMV感染对听力、智力的影响应引起长期关注。To study the effect of congenital human cytomegalovirus(CMV) infection on infants. Sixty-five neonates of congenital CMV infection and 82 uninfected subjects were measured hearing with TEOAE. They were followed up during 6 months to 4 years old. Follow-up contents were developmental Quotient (DQ) and hearing. Eight infants had low DQ in the infected group, but only one of the control subjects did. Statistic significance exists between the two groups. Seven neonates (9 ears) did not pass the TEOAE hearing screening, and then increased to 9 infants (11 ears) during the follow-up period in infected group. Only one case (1 ear) in the control group did not pass TEOAE from birth to follow-up days. The difference between the two groups is significant. TEOAE response intensity of two ears in infected group is lower than that of the control group both in the neonates and follow up days. Fourteen infants were test-ed by ABR, including 12 infected and 2 control infants. ABR shows: 9 infected infants (17 ears) com-pared with 1 control case (1 ear) had hearing impairment. We conclude that more attention should be paid to the effect of congenital CMV infection on infants for a long time. Key words: cytomegalovirus (CMV) developmental quotient(DQ), hearing transient evoked otoa-coustic emission( TEOAE) auditory brainstem response(ABR) .

关 键 词：先天性巨细胞病毒感染 婴幼儿 瞬态诱发性耳声发射 听力筛查 智力发育 血清学检测 

分 类 号：R725.1[医药卫生—儿科]