职业紧张对血清白细胞介素-6水平的影响  

Effect of Job Stress on Serum Interleukin-6 Level

作　　者：余善法[1] 姜开友[1] 杨艳[1] 谷桂珍[1] 王生[2] 

机构地区：[1]河南省职业病防治研究所,河南郑州450052 [2]北京大学医学部,北京100083

出　　处：《工业卫生与职业病》2003年第6期349-352,共4页Industrial Health and Occupational Diseases

基　　金：河南省医学科技创新人才工程项目 ( 2 0 0 1-2 3 )

摘　　要：目的　探讨职业紧张对白细胞介素 - 6 (IL 6 )分泌的影响。方法　采用横断面研究方法对 93名铁路货运调度员进行研究 ,使用职业紧张测量工具测试职业紧张因素、个性特征和紧张反应评分。采用放射免疫法分析血清中IL 6浓度。结果　方差分析结果表明 ,不同睡眠障碍评分组间血清IL 6浓度差异具有显著意义 (P <0 0 5 ) ,其余心理性紧张反应、职业紧张因素和个性特征评分组间血清IL 6浓度差异无显著意义 (P >0 0 5 )。相关分析显示 ,血清IL 6浓度与工作负荷、工作前景未知性和睡眠障碍评分呈正相关(P <0 0 5 ) ,而与其他职业紧张因素、紧张反应和个性特征变量评分无相关关系 (P >0 0 5 )。年龄、婚姻状态和文化程度与IL 6浓度无相关关系 (P >0 0 5 )。逐步回归分析结果显示 ,睡眠障碍和焦虑特性进入了回归方程 ,是血清IL 6浓度预测因子。结论　职业紧张对血清中ILObjective To explore the effects of job stress on serum interleukin 6(IL 6) level.Methods 93 male freight dispatchers in railway station were investigated for factors of job stress,characteristic personalities and job strains by questionnaires.Serum IL 6 was measured by radio immuno assay.Results ANOVA revealed that the subjects with variety of sleep disorders had higher level of serum IL 6(P<0 05), but the difference in the level of serum IL 6 did not show remarkable significance between groups of job stress factors,characteristic personalities and other strains(P<0 05).However,positive relationship was found in between serum IL 6 level and workload,future job ambiguity and sleep disorders(P<0 05).Other job stress factors,strains and characteristic personalities did not relate to serum IL 6 level(P>0 05).Age,marital status and education also did not relate to serum IL 6 level(P>0 05).Stepwise regression analysis showed that the sleep disorders (R 2=0 076) and anxiety trait( R 2=0 053 ) were the significant predictors of serum IL 6 level.Conclusions The occupational stress might result in the increase of serum IL 6 levels.

关 键 词：职业紧张 白细胞介素-6 免疫功能 血清水平 

分 类 号：R13[医药卫生—劳动卫生] R395.6[医药卫生—公共卫生与预防医学]