职业紧张对睾酮和催乳素分泌的影响  

Effect of Occupational Stress on Testosterone and Prolactin

作　　者：余善法[1] 姜开友[1] 马良庆[1] 杨艳[1] 李奎荣[1] 

机构地区：[1]河南省职业病防治研究所,河南郑州450052

出　　处：《工业卫生与职业病》2003年第6期352-356,共5页Industrial Health and Occupational Diseases

基　　金：河南省医学科技创新人才工程项目 ( 2 0 0 1-2 3 )

摘　　要：目的　探讨职业紧张对性激素睾酮和催乳素分泌的影响。方法　采用横断面研究方法对 93名铁路货运调度员进行调查 ,使用职业紧张测量工具测试职业紧张因素、个性特征和心理性紧张反应评分 ,采用放射免疫法分析血清中睾酮浓度 ,采用酶联免疫法分析血清中催乳素浓度。结果　方差分析显示 ,不同心理卫生、工作满意感、抑郁症和每日紧张感评分组间血清中催乳素浓度差异具有显著意义 (P <0 0 5或P <0 0 1 ) ,而其他紧张反应、职业紧张因素和个性特征评分组间血清中催乳素浓度差异均无显著意义(P >0 0 5 )。各职业紧张因素、紧张反应和个性特征评分组间血清中睾酮浓度差异均无显著意义(P >0 0 5 )。相关分析结果表明 ,血清催乳素浓度与心理卫生、抑郁症和每日紧张感评分呈显著正相关 ,与工作满意感评分呈显著负相关。血清中睾酮浓度与生活态度和外控性评分间呈显著负相关。年龄与血清中睾酮和催乳素浓度之间相关系数无显著意义 (P >0 0 5 ) ,婚姻状态与血清中睾酮浓度之间呈显著负相关 ,文化程度与血清中催乳素浓度之间呈显著正相关 (P <0 0 5 )。逐步回归分析表明 ,组织忠诚度、文化程度、心理卫生、应付策略和工作困难评分是血清催乳素浓度的预测因子 ,而自尊感和生活态度是血清睾酮浓度的预测因子。Objective To explore the relationship between occupational stress and serum testosterone and prolactin levels.Methods 93 male freight dispatchers in railway station were investigated for the factors of job stress,characteristic personalities,and job strains by questionnaires.Serum testosterone level was measured by radioimmunoassay and prolactin by enzyme immunoassay.Results ANOVA revealed that subjects with higher scores of mental health,job satisfaction,daily life strains and physical complaints had higher level of serum prolactin(P<0 05), but the their differences did not show remarkable significance in between the groups of job stress factors,personalities and other strains(P<0 05).The differences in levels of serum testosterone in group of all variables studied did not appear(P<0 05).Correlation analysis showed that serum prolactin level was positively related to mental health,depression,daily life stress,and negatively related to job satisfaction(P<0 05).Serum testosterone level was negatively related to self esteem and life attitude(P<0 05).Marital status was significantly and negatively related to serum testosterone,while education was positively related to serum prolactin(P<0 05).Multiple stepwise regression analysis showed that faithfulness to organization,education,mental health,coping strategy and job difficulty scores were predictors of the serum prolactin level,and self esteem and life attitude were predictors of the serum testosterone level.Conclusions The occupational stress might increase the level of serum prolactin.

关 键 词：职业紧张 个性特征 睾酮 催乳素 血清 

分 类 号：R13[医药卫生—劳动卫生] R395.6[医药卫生—公共卫生与预防医学]