GM-CSF和G-CSF治疗化疗后骨髓抑制的疗效比较  

Comparative Effect of GM-CSF and G-CSF After Chemotherapy

作　　者：邓涤[1] 周云峰[1] 伍钢[1] 程晶[1] 陈刚[1] 

机构地区：[1]湖北医科大学附属二院放化疗科,武汉430071

出　　处：《临床肿瘤学杂志》1999年第4期15-17,共3页Chinese Clinical Oncology

摘　　要：目的:比较GM-CSF和G-CSF治疗化疗后骨髓抑制的疗效.方法:对48例化疗后出现Ⅲ级以上骨髓抑制的患者,根据使用不同的升血药分为GM-CSF组和G-CSF组,观察造血刺激因子对中性粒细胞和血小板减少的治疗作用及毒副作用.结果:G-CSF组中性粒细胞恢复较快,但停药后GM-CSF组中性粒细胞数更稳定,GM-CSF可促进血小板回升,中性粒细胞减少性发热及持续天数两组无差异.副作用总发生率无差异.结论:GM-GSF和G-CSF均能有效治疗化疗后骨髓抑制,G-CSF作用较迅速,而GM-CSF作用更稳定.Objective: Comparting the effect that GM-CSF and G-CSF were used for treating the hematologic toxicity after chemotherapy. Method: Fouty - eight patients who had Ⅲ-Ⅳ°hematologic toxicity after chemotherapy were treated with GM -CSF or G-CSF. The effects were compared that GM-CSF or G-CSF treated the reduction of neutroprill and platelet, comparative the rate of side effects. Results: Neutrophil recovery was faster after G-CSF administration. The counts of neutropril were more ballast with GM- CSF. Platelet counts could recovere more rapidly with GM - CSF administration. No significant difference was observed between the two groups concerning days of absolute neutropenia and neutropenic fever. The rate of all side effects was no significant difference between the two groups. Conclusions: Useing G-CSF or GM-CSF can treat the hematologic toxicity after chemotherapy, the effect of G- CSF is more rapidly, and the GM- CSF more ballast.

关 键 词：GM-CSF G-CSF 治疗 化疗 骨髓抑制 药物 

分 类 号：R453[医药卫生—治疗学]