旱莲草对老年小鼠脾淋巴细胞的作用  

Biological Activity of Elipta on the Aged Mice Splenolymphocytes

作　　者：冯明功[1] 才迎[1] 陈群[1] 

机构地区：[1]大连大学医学院检验系,辽宁大连116622

出　　处：《大连大学学报》1999年第4期74-77,80,共5页Journal of Dalian University

摘　　要：方法：观察了老年小鼠服旱莲草水煎剂后，脾淋巴细胞IL2、MAF的分泌和DNA合成的变化；并观察了旱莲草体外对脾淋巴细胞DNA合成的影响．结果：①使老年小鼠脾淋巴细胞分泌IL2逐渐减少（P＜0.001），并呈剂量依赖关系（r=-8988）；②体内外实验表明高浓度旱莲草水煎剂抑制脾淋巴细胞在ConA激活后的DNA合成，但无ConA时DNA合成不受影响;③老年小鼠脾淋巴细胞分泌MAF能力明显低于青年小鼠（P＜0.05），灌服旱莲草24g/kg×7d使老年小鼠脾淋巴细胞分泌MAF能力明显增强（P＜0.05）．In order to study the function of macrophage and effect of elipta extracts on immunologic function in aged mice, We examined from splenolymphocyte IL-2, MAF and the ability of DNA synthesis after administering the different concentration of eclipta decoctum.①The result showed that in aged mice, the different concentration ecliptas have no significant effects and have dosedependent relationship in restraining IL-2 produced by splenolylnphocyte (P<0.001, r=-0.898 8), ② In vitro and vivo DNA synthesis with ConA were. suppressed in dosedependent relationship by different concentration eclipta decoctum, especially in two high concentration groups, whereas, the suppression disappeared in the absence of ConA, ③ The ability of MAF secrted by aged mice is lower than that of young mice (P<0.05). but the ability of MAFsecreted by aged mice increased obviously after it was taken elipta (P<0.05).

关 键 词：旱莲草 脾淋巴细胞 中药 DNA HEP 

分 类 号：R284[医药卫生—中药学]