慢型克山病患者血清Ⅰ型前胶原羧基末端肽浓度的变化  

Change of serum concentrations of procollagen typeⅠcarboxy-termina l peptide in patients with chronic Keshan Disease

作　　者：韩福生[1] 周令望[1] 刘立志[1] 高彦辉[1] 孙辉[1] 刘艺[1] 郭新利[1] 汪中伯[1] 于波[2] 钟学宽[1] 于维汉[1] 

机构地区：[1]哈尔滨医科大学中国疾病预防控制中心地方病控制中心克山病防治研究所,黑龙江哈尔滨150086 [2]哈尔滨医科大学附属第二医院心血管内科,黑龙江哈尔滨150086

出　　处：《中国地方病学杂志》2003年第6期507-508,共2页Chinese Jouranl of Endemiology

基　　金：黑龙江省科学技术计划项目资助 (G 0 0C1 90 90 3)

摘　　要：目的　探讨慢型克山病患者血清Ⅰ型前胶原羧基末端肽 (PⅠCP)浓度的变化。方法　用ELISA方法测定了观察对象的血清PⅠCP的浓度。结果　黑龙江省慢型克山病患者血清PⅠCP浓度 (56.42± 8.10 ) μg/L显著高于病区正常人 (49.2 1± 4.98) μg/L(P <0 .0 1) ;病区正常人的血清PⅠCP浓度显著高于非病区正常人(40 .85± 6.75) μg/L(P <0 .0 0 1)。四川省病区正常儿童血清PⅠCP(52 .53± 12 .91) μg/L高于非病区正常儿童(45.91± 6.0 2 ) μg/L ,但无统计学意义 (P >0 .0 5)。结论　慢型克山病患者机体胶原合成活跃 ,血清PⅠCP有可能成为监测慢型克山病的一个指标 ;ObjectiveTo investigate the change of serum concentration of procollagen type Ⅰ carboxy-terminal peptide (PⅠCP) of patien ts with chronic Keshan disease.MethodsPⅠCP levels of patients with chronic Kehsan di sease and healthy persons in endemic area and non-endemic area of Keshan diseas e in Heilongjiang province were measured by ABC-ELISA, and PⅠCP levels of chil dren in endemic area and non-endemic area of Keshan disease in Sichuan province were also measured.ResultsPⅠCP levels of patients with chronic Keshan di sease were significantly higher than those of healthy persons in endemic area, i n turn, than those of healthy persons in non-endemic area in Heilongjiang provi nce(P<0.01). PⅠCP levels of children in endemic area were higher than those of children in non-endemic area in Sichuan province, but no statistical significance was found(P>0.05).ConclusionsThe measurement of serum concentrations of PⅠCP may reflect the collagen synthesis in patients with chronic Keshan disease and may be a new marker in monitoring chronic Keshan disease; abnormal metaboli sm of collagen in the healthy persons in endemic area need to be studied in deta il.

关 键 词：慢型克山病 血清 Ⅰ型前胶原羧基末端肽 浓度变化 

分 类 号：R542.3[医药卫生—心血管疾病]