小鼠耐力训练后再力竭运动对体内某些生化指标的影响  

EFFECTS OF EXHAUSTIVE EXERCISE ON BIOCHEMICAL INDEXES OF ENDURANCE-TRAIN ED MICE

作　　者：张全江[1] 李秋霞[1] 熊正英[1] 张全海[1] 

机构地区：[1]陕西师范大学运动生物学研究所,陕西西安710062

出　　处：《中国应用生理学杂志》2003年第4期363-366,共4页Chinese Journal of Applied Physiology

基　　金：陕西师范大学青年科学基金资助

摘　　要：目的 :通过分析耐力训练后再力竭运动小鼠部分生化指标的变化来探讨耐力训练提高机体抗疲劳能力可能机制及血液再分配的机制。方法 :建立耐力训练后再力竭运动模型 ,测定血清中超氧化物歧化酶 (SOD)活性、过氧化物酶 (POD)活性、过氧化氢酶 (CAT)活性与丙二醛 (MDA )含量及肝、骨骼肌、心肌与血清中一氧化氮 (NO )含量。结果 :运动后即刻 ,非耐力组血清SOD活性及肝NO含量较安静组显著下降 (P <0 .0 5～ 0 .0 1) ,而血清POD与CAT活性及骨骼肌与血清NO含量则显著升高 (P <0 .0 5～ 0 .0 1) ,其余指标无显著变化 (P >0 .0 5)。耐力组CAT活性显著高于非耐力组 (P <0 .0 5) ,血清NO含量显著低于非耐力组 (P <0 .0 1) ,其余指标两组间无显著差异 (P >0 .0 5)。 2 4h恢复后 ,非耐力组血清CAT活性与MDA含量及肝NO较运动后即刻显著升高 (P <0 .0 5～ 0 .0 1) ,血清与骨骼肌NO含量显著下降 (P <0 .0 5) ,而其余指标则无显著变化 (P >0 .0 5)。耐力组血清SOD活性及肝、血清与心肌NO含量较运动后即刻显著升高 (P <0 .0 5) ,而血清CAT活性显著下降 (P <0 .0 5) ,其余指标无显著变化(P >0 .0 5)。耐力组血清CAT活性与MDA含量显著低于非耐力组 (P <0 .0 5) ,而心肌NO含量显著高于非耐力组 (P <0 .0 5) ,其余指标两组间?Aim: To observe possible mechanism that endurance training can enhance a nti-fatigue capability, and that blood redistribution by analyzing some bioch emical indexes of endurance-trained mice after exhaustive exercise. Met hods: The model was set up by exhaustive exercise. The indexes include t he activity of SOD, CAT and POD and the MDA content in serum and the NO content in liver, muscle, heart and serum. Results: After exhaustive exe rcise, the SOD activity in serum and the NO content in liver significantly decre ase(P<0.05～0.01), and the activity of POD and CAT, the NO content in serum and muscle significantly increase(P<0.05～0.01), but the rest insignificantl y change in non-endurance(P>0.05). In endurance group, the CAT activity in serum are significantly higher than in non-endurance(P<0.05), and the NO co ntent in serum is significantly lower than in non-endurance(P< 0.01 ), bu t the rest are insignificantly different between two groups(P>0.05).After 24 h restoration, in non-endurance group, the CAT activity and the MDA content in serum and the NO content in liver significantly rise(P<0.05～0.01), and the NO content in muscle and serum significantly decrease(P<0.05),but the rest insignificantly change(P>0.05). In endurance group, the SOD activity in seru m and the NO content in liver, serum and heart significantly rise(P<0.05), a nd the CAT activity in serum significantly decreases(P<0.05), but the rest i nsignificantly change(P>0.05). In endurance group, the CAT activity and the MDA content in serum are significantly lower than in non-endurance(P<0.05), but the NO content in heart is higher than in non-endurance(P< 0.05 ).Th e rest are insignificantly different between two groups(P>0.05).Conclu sion: The possible mechanism, which endurance training can enhance anti-f atigue capability, is relative to enhance the capability to resume balance. Bloo d redistribution are possibly relative to change to the NO content.

关 键 词：耐力训练 力竭运动 血液 生化指标 运动 细胞损伤 

分 类 号：R873[医药卫生—运动医学]