银屑病患者血浆内皮素-1检测及其临床意义  

Clinical significance and determination of plasma endothelin-1 in patients with psoriasis

作　　者：胡白[1] 高银花[1] 张思平[1] 西羽中 凌曦[3] 

机构地区：[1]安徽省立医院皮肤科,安徽合肥230001 [2]安徽省皮肤性病防治所,安徽合肥230031 [3]安徽省立医院防保科,安徽合肥230001

出　　处：《疾病控制杂志》2003年第6期525-526,共2页Chinese Journal of Disease Control and Prevention

摘　　要：目的　探讨血浆内皮素 - 1在银屑病进行期和静止期水平的变化及其与银屑病发病机制的关系。方法　用放射免疫分析法检测 6 9例寻常型银屑病患者血浆中内皮素 - 1的水平 ,其中进行期 4 1例 ,静止期 2 8例 ,并与 2 2例健康者进行对照。结果　银屑病患者血浆内皮素 - 1高于正常对照组 (P <0 .0 5 ) ,且进行期银屑病患者血浆内皮素 - 1高于正常对照组 (P <0 .0 5 ) ,也高于静止期银屑病患者 (P <0 .0 5 )。结论　血浆内皮素 -Objective To explore the change of plasma endothelin-1 (ET-1) in progressive or stationary stage of psoriasis patients, and find the relation between ET-1 and the pathogenesis of psoriasis. Methods Radioimmunoassay (RIA) was used to detect plasma ET-1 levels in 69 psoriasis vulgaris, including 41 patients in progressive stage, 28 patients in stationary stage and 22 healthy controls. Results The result revealed that plasma ET-1 level in patients with psoriasis was significantly higher than that of normal control group (P<0.05), and plasma ET-1 level in progressive stage of psoriasis was significantly higher than that of normal control group (P< 0.05). In addition, plasma ET-1 level in progressive stage of psoriasis patients was significantly higher than that in stationary stage (P< 0.05). Conclusions The increase of plasma ET-1 level may be associated with psoriasis in progressive stage.

关 键 词：银屑病 血浆 内皮素 ET 血标本 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]