益气活血法与血管平滑肌细胞基因表达调节  

Supplementing Qi and activating blood circulation in gene regulation of vascular smooth muscle cells

作　　者：温进坤[1] 韩梅[1] 

机构地区：[1]河北医科大学基础医学研究所,河北石家庄050017

出　　处：《中西医结合学报》2003年第1期12-14,共3页Journal of Chinese Integrative Medicine

基　　金：国家自然科学基金资助项目 (3 9970 2 74)

摘　　要：多种心血管疾病的发生发展都与血瘀证有关 ,采用益气活血法作为治疗该类疾病的主要治则已广泛用于临床。研究证实 ,益气活血中药可调整舒缩血管活性肽在血管平滑肌细胞中的表达活性 ;并通过抑制血管平滑肌细胞表型转化和细胞增殖相关基因表达而减缓血管内膜增生程度。该类药物还具有调节细胞外基质代谢从而抑制基质重构和血管平滑肌细胞黏附与迁移的作用。本文将近年有关益气活血中药调节血管平滑肌细胞行为及其分子机制的研究作一评述。According to the theory of traditional Chinese medicine, blood stasis is a main pathological mechanism in the development of vascular diseases.Supplementing Qi and activating blood circulation, as the therapeutic principle for the blood stasis, has been adapted.Studies demonstrated that the supplementing Qi and activating blood circulation recipe could regulate the expression of vasoactive peptides in vascular smooth muscle cells (VSMCs). The recipe inhibited the formation of neointima following arterial intimal lesions through down regulating expression of proliferation related genes and phenotypic modulation of VSMCs. The recipe also markedly inhibited the adhesion and migration of VSMCs and matrix remodelling by means of a mechanism that balances extracellular matrix turnover rate. The purpose of this review is to summarize the recent advances made in our understanding of new functions for the recipe in regulating VSMCs behaviours and their microenvironment relevant to vascular diseases and maintaining proper homeostasis.

关 键 词：益气活血法 血管 平滑肌细胞 基因表达 治疗 

分 类 号：R242[医药卫生—中医临床基础] R2-03[医药卫生—中医学]