山东产四种菟丝子免疫增强作用的比较研究  

Comparative study on immune enhancement effects of four kinds of dodder seeds in Shandong Province

作　　者：林慧彬[1] 林建强[2] 林建群[2] 路宁 衣秀义[1] 

机构地区：[1]山东省中医药研究院,山东济南250014 [2]山东大学生命科学院,山东济南250100 [3]青岛双鲸药业有限公司,山东青岛266000

出　　处：《中西医结合学报》2003年第1期51-53,共3页Journal of Chinese Integrative Medicine

基　　金：山东省自然科学基金资助项目 (Q99C0 1)

摘　　要：目的　比较山东产四种菟丝子对小鼠免疫功能、抗疲劳、耐缺氧等方面的作用。方法　选用昆明种小鼠 ,用山东产四种菟丝子的水、醇提取物灌胃 ,观察小鼠腹腔巨噬细胞吞噬功能、免疫器官重量的变化、游泳实验和耐缺氧等指标。结果　山东产四种菟丝子均可增加小鼠吞噬百分率 ,使幼龄小鼠的胸腺和脾脏增重 ,并可显著延长小鼠的游泳及缺氧存活时间。其中以菟丝子和南方菟丝子的作用较好 ,水提取物的作用优于醇提取物。结论　山东产四种菟丝子具有增强机体免疫功能、抗疲劳、耐缺氧作用。菟丝子中的多糖是其提高机体免疫力 ,增强体质的有效物质之一。Objective To compare the effects of immune enhancement, anti fatigue and anoxia tolerance on mice of four kinds of dodder seeds in Shandong Province. Methods Water extracts and alcohol extracts of the four kinds of dodder seeds were administered to mice. The phagocytosis of coelio macrophage, the weight changes of the immune organs, the survival time to swimming and lacking of oxygen were observed. Results The four kinds of dodder seeds in Shandong Province could enhance the phagocytosis of macrophage of mice and increase the weights of thymus and spleen of the immature mice. They could prolong the survival time of mice swimming and lacking oxygen Cuscuta chinensis Lam. and C. australis R. Br.had better effects than the other two kinds,and the water extracts had better effects than alcohol extracts. Conclusion The four kinds of dodder seeds in Shandong Province have the effects of immune enhancement, anti fatigue and anoxia tolerance. The polysaccharide in dodder seeds is one of the effective materials to improve the immune system.

关 键 词：山东 菟丝子 免疫器官 小鼠 中药 

分 类 号：R285[医药卫生—中药学]