青香丸(浓缩丸)对大鼠乳腺增生的影响  

Experimental Study on Effects of Qingxiang Concentrated Pill on Mammary Gland Hyperplasia in Rats

作　　者：马雪瑛[1] 林成仁[1] 王敏[1] 石体仁[1] 宗红心 李连达[1] 

机构地区：[1]中国中医研究院西苑医院基础医学研究室,北京100091 [2]长甲集团,上海201206

出　　处：《中药新药与临床药理》2003年第6期375-378,共4页Traditional Chinese Drug Research and Clinical Pharmacology

摘　　要：目的 观察青香丸(浓缩丸)对大鼠实验性乳腺增生的影响。方法 给雌性未孕大鼠注射苯甲酸雌二醇复制乳腺增生病理模型,造模的同时灌胃给药,测定乳房直径、乳腺体积及重量、脏器系数、血清性激素水平、超氧化物歧化酶(SOD)活性、丙二醛(MDA)含量,同时镜下观察乳腺组织病理形态学变化。结果 青香丸(浓缩丸)明显减小大鼠增生乳房直径、乳腺体积和重量,减少乳腺小叶数、腺泡数和腺泡腔直径;并且明显抑制胸腺系数的减少,显著降低血清雌二醇(E_2)和MDA含量,对血清孕酮(P)水平有升高趋势。结论 青香丸(浓缩丸)具有调节性激素水平、抑制脂质过氧化、减轻乳腺组织增生性病变的作用。Objective To observe the therapeutic effect of Qingxiang Concentrated Pill (QCP) on mammary gland hyperplasia (MGH) in rats. Methods Injection of estradiol were given to establish rat models of MGH and QCP was given QCP at the same time. Pathologic changes of mammary gland in rats were observed under light microscope. Changes of breast diameter, mammary gland volume and weight were measured; serum sex hormones levels, SOD activity and MDA content were also estimated. Results QCP could decrease the increased breast diameter, mammary gland volume and weight, reduce the numbers of mammary gland lobules and mammary acini and the diameter of acinar cavities. It could also decrease eatradiol level and MDA content in serum, inhibit the decrease of the coefficient of thymus and increase the serum progesterone level. Conclusion QCP can regulate sex hormone levels, inhibit lipid peroxidation and relieve the pathologic changes of mammary gland in MGH rats.

关 键 词：青香丸/药理学 纤维囊性病 乳腺/中药疗法 纤维囊性病 乳腺/病理生理学 动物疾病模型 

分 类 号：R655.8[医药卫生—外科学] R285.5[医药卫生—临床医学]