The Preparation of 2-Chloro-5-chloromethylpyridine in an Airlift Loop Reactor  

作　　者：闻建平 王长林 乔萍 

机构地区：[1]School of Chemical Engineering and Technology,Tianjin University, Tianjin 300072, China

出　　处：《Chinese Journal of Chemical Engineering》2003年第5期608-610,共3页中国化学工程学报（英文版）

基　　金：Natural Science Foundation of Tianjin(No.013605711);National Natural Science Foundation of China(No.20176040)

摘　　要：A new process for the direct chlorination of 2-chloro-5-methylpyridine to yield 2-chloro-5-chloro-methylpyridine in an airlift loop reactor (ALR) has been studied. Five main reaction conditions including TR, na/ns, cp, Qg and dD/dR were optimized. The average molar yield and purity of 2-chloro-5-chloromethylpyridine obtained were 79% and 98.5% respectively under the optimum operating conditions. Finally, the efficiency for the preparation of 2-chloro-5-chloromethylpyridine with ALR and stirred tank reactor (STR) respectively was compared.A new process for the direct chlorination of 2-chloro-5-methylpyridine to yield 2-chloro-5-chloro-methylpyridine in an airlift loop reactor (ALR) has been studied.Five main reaction conditions including TR,na/ns,cp,Qg and dD/dR were optimized.The average molar yield and purity of 2-chloro-5-chloromethylpyridine obtained were 79% and 98.5% respectively under the optimum operating conditions.Finally,the efficiency for the preparation of 2-chloro-50chloromethylpyridine with ALR and stirred tank reactor(STR) respectively was compared.

关 键 词：2-chloro-5-chloromethylpyridine 2-chloro-5-methylpyridine direct chlorination airlift loop reactor 

分 类 号：TQ25[化学工程—有机化工]