玉米醇溶蛋白-肝素微球的制备和缓释  

The Preparation and the Release Kinetics of Zein-Heparin Microspheres

作　　者：王华杰[1] 王林嵩[1] 王瑾晔[2] 

机构地区：[1]河南师范大学生命科学学院,新乡453002 [2]中国科学院上海有机化学研究所,上海200032

出　　处：《科学技术与工程》2003年第6期557-560,共4页Science Technology and Engineering

基　　金：国家重大科研项目863计划(2002AA327100)

摘　　要：为了开发一种stent涂层材料,使其具有一定的肝素缓释效果,以期对stenting技术中急性血栓形成的预防有所助益,通过对玉_米醇溶蛋白-肝素微球的制备方法、微球粒径控制、体外肝素的释放动力学等方面进行了系统研究,结果表明:玉米醇溶蛋白、肝素微球粒径可控,并具有一定的缓释效果。The purpose was to develop a coating material encapsulating heparin, which could be sustainedly released. The preparation, the size, and the release kinetics of zein-heparin microspheres were studied, The results show that the size of zein-heparin microspheres could be controlled and 80% of heparin is released after two days.

关 键 词：玉米醇溶蛋白 肝素微球 制备 缓释 涂层材料 急性血栓 抗凝血药物 

分 类 号：R973.2[医药卫生—药品]