冠心病患者血浆同型半胱氨酸与氧化低密度脂蛋白水平及其关系  

Relationship Between Levels of Plasma Homocysteine and Oxidative LDL in Coronary Heart Disease

作　　者：李晓东[1] 马淑梅[1] 孙亚清[1] 孙志军[1] 邹德玲[1] 杨智勇[1] 曹乾[1] 王丽君[1] 丁良柱 

机构地区：[1]中国医科大学附属第二医院心内科,辽宁沈阳110004 [2]黑龙江省伊春市乌拉嘎林业医院

出　　处：《中国医科大学学报》2003年第6期549-550,共2页Journal of China Medical University

摘　　要：目的 :探讨冠心病患者血浆同型半胱氨酸 (Hcy)水平及氧化低密度脂蛋白 (ox LDL)水平及相关关系。方法 :选择冠心病患者 85例 ,正常对照组 32例。以全自动荧光偏振免疫分析法测定Hcy ,用ELISA方法测定ox LDL。结果 :85例冠心病患者与正常对照组血浆Hcy分别为 (14 .73± 5 .32 ) μmol/L和 (9.32± 4 .72 ) μmol/L ,差异显著(P <0 .0 1)。冠心病患者与正常对照组血ox LDL分别为 (712 .83± 2 13.92 ) μg/L和 (40 2 .13± 187.6 1) μg/L ,差异显著 (P <0 .0 1)。冠心病患者中Hcy与ox LDL呈显著正相关 (Y =0 .76 ,X =1.9,r =0 .72 5 ,P <0 0 1)。结论 :Hcy及Ox LDL参与冠心病的发生发展过程冠状动脉粥样硬化的形成 ,可能与冠心病的严重程度关系不大。Objective: Our purpose was to provide theoretical basis for prevention and treatment of coronary heart disease(CHD) by determining the levels of plasma homocysteine(Hcy) and oxidative low density lipoprotein (ox LDL) and their relationship. Methods: Patients (85) with CHD and 32 healthy controls were examined. The Hcy was determined with a fluorescent derivative using high performance liquid chromatography. The ox LDL was determined with ELISA method. Results: Levels of homocysteine of CHD cases and controls were (14.73±5.32) μmol/L and (9.32±4.72) μmol/L, respectively. The difference was significant (P<0.01). Levels of ox LDL of CHD cases and controls were (712.83±213.92) μg/L and (402.13±187.6) μg/L, respectively. The difference was significant (P<0.01). A significant positive correlation was found between level of homocysteine and ox LDL in CHD cases(Y=0.76,X=1.9, r=0.725,P<0.01). Conclusion: Homocystenie and ox LDL have involved in the pathogenesis of coronary arteries atherosclerosis and CHD. However, there is no relationship with the severity of CHD.

关 键 词：冠心病 血浆同型半胱氨酸 氧化低密度脂蛋白 

分 类 号：R541.4[医药卫生—心血管疾病]