A　COMPLEX　OF　INTERMEDIATE　FILAMENT　PROTEIN－DNA：A　TARGET　FOR　AUTOANTIBODIES　IN　SYSTEMIC　LUPUS　ERYTHEMATOSUS？  

作　　者：阎锡蕴 

机构地区：[1]InstituteofMicrobiology,ChineseAcademyofScience,Beijing100080

出　　处：《Chinese Medical Sciences Journal》1995年第2期90-92,共3页中国医学科学杂志（英文版）

摘　　要：Autoantibodies in systemic lupus erythematosus which cross-react with double stranded DNA and intermediate filament proteins are frequently reported. However, little is Known about the origin and the target of these antibodies. In this paper, a polyspecific monoclonal antibody, XY12, produced by the immunization of genetically non-autoimmune mice with a DNA-protein complex is detailed. Its antigen binding patterns are very similar to the autoantibodies. The data suggest that these autoantibedies may be triggered by a circulating nucleoprotein.

关 键 词：monoclonal antibody lupus erythematosus AUTOANTIBODY 

分 类 号：R593.241[医药卫生—内科学]