Healthy ranges of serum alanine aminotransferase levels in Iranian blood donors  

作　　者：Mehdi Mohamadnejad Akram Pourshams Reza Malekzadeh Ashraf Mohamadkhani Afsaneh Rajabiani Ali Ali Asgari Seyed Meysam Alimohamadi Hadi Razjooyan Mansooreh Mamar-Abadi 

机构地区：[1]Digestive Disease Research Center,Tehran University of Medical Sciences,Tehran,Iran [2]Department of Pathology,School of Medicine,Tehran University of Medical Sciences,Tehran,Iran

出　　处：《World Journal of Gastroenterology》2003年第10期2322-2324,共3页世界胃肠病学杂志（英文版）

摘　　要：AIM: The healthy ranges for serum alanine aminotransferase(ALT) levels are less well studied. The aim of this study was to define the upper limit of normal (ULN) for serum ALT levels, and to assess factors associated with serum ALT activity in apparently healthy blood donors. METHODS: A total of 1 939 blood donors were included.ALT measurements were performed for all cases using the same laboratory method. Healthy ranges for ALT levels werecomputed from the population at the lowest risk for liver disease. Univariate and multivariate analyses were performed to evaluate associations between clinical factors and ALT levels.RESULTS: Serum ALT activity was independently associated with body mass index (BMI) and male gender, but not associated with age. Association of ALT with BMI was more prominent in males than in females. Upper limit of normal for non-overweight women (BMI of less than 25) was 34 U/L,and for non-overweight men was 40 U/L.CONCLUSION: Serum ALT is strongly associated with sex and BMI. The normal range of ALT should be defined for male and female separately.AIM:The healthy ranges for serum alanine aminotransferase (ALT) levels are less well studied.The aim of this study was to define the upper limit of normal (ULN) for serum ALT levels,and to assess factors associated with serum ALT activity in apparently healthy blood donors. METHODS:A total of 1939 blood donors were included. ALT measurements were performed for all cases using the same laboratory method.Healthy ranges for ALT levels were computed from the population at the lowest risk for liver disease.Univariate and multivariate analyses were performed to evaluate associations between clinical factors and ALT levels. RESULTS:Serum ALT activity was independently associated with body mass index (BMI) and male gender,but not associated with age.Association of ALT with BMI was more prominent in males than in females.Upper limit of normal for non-overweight women (BMI of less than 25) was 34 U/L, and for non-overweight men was 40 U/L. CONCLUSION:Serum ALT is strongly associated with sex and BMI.The normal range of ALT should be defined for male and female separately.

关 键 词：ADOLESCENT ADULT Age Distribution Aged Alanine Transaminase Blood Donors Body Mass Index Chemistry  Clinical numerical data CHILD Female Humans Iran Logistic Models Male Middle Aged Reference Values Sex Distribution 

分 类 号：R446.1[医药卫生—诊断学]