核转录因子PPARγ2的研究进展  

Advances of Nuclear Translation Factor:Peroxisome Proliferator-actived Receptor γ2

作　　者：孙玉茹[1] 杨泽[1] 

机构地区：[1]卫生部北京医院卫生部北京老年医学研究所医学遗传研究室,北京100730

出　　处：《遗传》2003年第6期713-717,共5页Hereditas（Beijing)

基　　金：国家自然科学基金(39970399);科技部973课题(G2000057009);国家863计划(2002AA223031)

摘　　要：过氧化物酶增殖物激活受体γ2 (PPARγ2 )是一个转录因子 ,属于核受体超家族的成员之一。其主要在脂肪组织表达 ,对脂肪细胞分化进行调控。其常见多态性Pro12Ala已发现与肥胖及 2型糖尿病关系密切。它也是治疗糖尿病药物噻唑烷二酮类药物 (TZDs)作用的靶分子。因此 ,对其进行代谢调控分子机制的研究 ,可能有助于对Peroxisome proliferator-actived receptor γ2(PPARγ2) is a translation factor that belongs to the superfamily of nuclear receptors.It expresses predominantely in adipose tissue and has a key role in adipocyte differentiation.The common Pro12Ala polymorphism is associated closely with obesity and type 2 diabetes.It is the target molecular of thiazolidinediones which is a novel class of insulin sensitizer.The study of PPARγ2 molecular mechanism of metabolism control may accelerate the finding of new drug targets in prevention and therapeution of type 2 diabetes.

关 键 词：2型糖尿病 肥胖 多态性 过氧化物酶增殖物激活受体γ2 

分 类 号：Q75[生物学—分子生物学]