肺癌合并下呼吸道感染菌种的变迁及药敏分析(英文)  

Analysis of drug-sensibility and pathogen variance of lower respiratory tract infection accompanying lung cancer

作　　者：李也鹏[1] 胡成平[1] 杨红忠[1] 罗百灵[1] 

机构地区：[1]中南大学湘雅医院呼吸内科,长沙410008

出　　处：《中国现代医学杂志》2003年第22期50-53,共4页China Journal of Modern Medicine

摘　　要：目的　通过对比分析两个不同时期肺癌患者合并下呼吸道感染的致病菌和对抗生素的敏感性 ,为临床合理使用抗生素提供依据。方法　以 1991年 372例和 2 0 0 1年 5 72例我院肺癌住院病人为研究对象进行回顾性研究。结果　 1991年组革兰氏阳性菌 (GPC)占 2 6 .8% ,革兰氏阴性菌 (GNB)占 6 2 5 % ,2 0 0 1年组GPC占 38.5 % ,GNB占 5 0 % ;1991年组主要病原菌为克雷伯杆菌 (2 6 .8% )、金葡茵 (16 .1% )、肠杆菌(14 .3% )、绿脓杆菌 (12 .5 % ) ,2 0 0 1年组主要为肠杆菌 (17.3% )、肺炎链球菌 (13.5 % )、霉菌 (11.5 % )、流感嗜血杆菌 (9.6 % )和表皮葡萄球菌 (9.6 % )。结论　两组致病菌均以革兰氏阴性菌为主 ,但 2 0 0 1年主要致病菌的分布发生了变迁 ,革兰氏阳性菌和条件致病菌、霉菌所占比例增高。药敏分析显示 2 0 0 1年来多种抗生素的敏感性较 1991年有所下降 ,但现常用抗生素仍然有效。Objective:For the reasonable use of antibiotics, pathogens for lower-respiratory-tract infection and their drug sensibility were contrastively analyzedin lung cancer patients during two different periods.Methods:The medical records of 372 patients in 1991 and 572 patients in 2001 were retrospectively studied.Results: The gram-positive cocci(GPC) ccounted for 26.8% and the Gram-negative bacilli(GNB) for 62.5% in 1991;GPC in 2001 accounted for 38.5% and GNB for 50% in 2001.The predominant bacteria were in the following order:Klebsiella(26.8%),Staphylococcus aureus(16.1%), Enteric bacilli(14.3%),Pseudomonas(12.5 %) in 1991;and Enteric bacilli(17.3 %),Pneumococcal(13.5 %),Mold(11.5 %),Heamophilus(9.6 %),Staphylococcus epidermis(9.6 %).Conclusions:The predominant bacteria in the two groups were both Gram-negative bacilli,however,the ratio of gram-positive cocci, conditioned pathogens and mold was higher in 2001 than in 1991.The sensibility of many drugs in 2001 fell in various degrees compared with that in 1999,but croutine antibiotics are still effective now.

关 键 词：肺癌 下呼吸道感染 菌种变迁 药物敏感性 

分 类 号：R563[医药卫生—呼吸系统]