天南星中草酸钙针晶形态炮制前后变化比较  

Study of Stinging Crystals in Tian Nanxing

作　　者：赫炎[1] 冯雪峰[1] 孙洁[1] 王祝举[1] 

机构地区：[1]中国中医研究院中药研究所,北京100700

出　　处：《中国中药杂志》2003年第11期1015-1018,共4页China Journal of Chinese Materia Medica

摘　　要：目的 :提供天南星样的刺激作用是由其草酸钙针晶尖端所至的实验证据。方法 :从炮制前后及加工过程的动态变化 ,对天南星中草酸钙针晶的显微及超微改变进行了定性定量观察 ,并结合同批样品刺激反应的时效及量效数据的定量分析为南星的刺激物质的确定提供相关证据。结果与结论 :毛须针晶不同含量的天南星具有不同刺激作用。天南星中草酸钙针晶尖端变化率与兔眼结膜刺激反应呈量效关系 (r =0 .995) ;与矾水浸泡时间呈时效关系 (r =0 .993 )。Objective: To test whether the raphides in T ian Nanxing(Pinellia pedatisecta Schott) caused irritation. Method: Scan Electron Microscope and Microscope Oberservation; Animal experime ntal study. Result: Through the comparision of unproceesed Tian Nanxing to proceesed ones which included 36 h, 72 h ,120 h proceesed sampl es, the great modifications in the structure of raphides, especially for the one s with barbs in the proceesed samples was observed with time course study. A fur ther animal experimental study went to show that the rate of change for raphides with barbs existed a dose-reponse relationship to irritation. Conclusion: Investigations of the causes of these reactions showed that raphides of calcium oxalate are, at least in part, responsible for the Tian Nanxing's irritation.

关 键 词：天南星 草酸钙针晶 形态 炮制前 炮制后 

分 类 号：R283.1[医药卫生—中药学]