磷酸萘酚喹治疗恶性疟的疗效初步观察  

PRIMARY OBSERVATION ON EFFICACY OF NAPHTHOQUINE PHOSPHATE ON THE TREATMENT OF PLASMODIUM FALCIPARUM MALARIA

作　　者：单成启[1] 刘光裕[1] 焦岫卿[1] 

机构地区：[1]军事医学科学院微生物流行病研究所,北京100071

出　　处：《寄生虫与医学昆虫学报》2003年第4期198-201,共4页Acta Parasitologica et Medica Entomologica Sinica

摘　　要：目的 :观察磷酸萘酚喹与氯喹治疗恶性疟的临床疗效。方法 :以显微镜血检单纯恶性疟原虫阳性患者为观察对象 ,药物为磷酸萘酚喹 ,成人总量 10 0 0mg ,首次 6 0 0mg ,2 4h服 4 0 0mg ,服药后按时测量体温和血检原虫 ,随访 2 8天 ,观察治疗效果。结果 :磷酸萘酚喹治疗 4 0例 ,平均退热时间为 (35 9± 16 7)h ,原虫转阴时间为 (6 1 7± 18 1)h ,治愈率为 10 0 %。药后无明显不良反应。结论 :磷酸萘酚喹治疗恶性疟疾具有良好的效果。Objective To observe the clinical therapeutic efficacies of naphthoquine phosphate and chloroquine phosphate in patients with Plasmodium falciparum malaria.Methods Patients with Plasmodium falciparum were selected as the subjects,treated with a single dose of naphthoquine phosphate(1 000mg) and followed up in preselective time by blood and temperature examination for 28 days after drug administration.Results 40 patients with Plasmodium falciparum malaria were treated and followed up.The mean fever clearance time was 35 9±16 7hours;the mean parasite clearance time was(61 7±18 1)hours.The cure rate was 100%.No apparent side effect was observed.Conclusion Naphthoquine phosphate is effective for the treatment of patients with Plasmodium falciparum malaria.

关 键 词：磷酸萘酚喹 磷酸氯喹 恶性疟 治疗 疟疾 

分 类 号：R531.3[医药卫生—内科学] R382.31[医药卫生—临床医学]