急性冠状动脉综合征患者血清C-反应蛋白的改变  

The Changes of C-reactive Protein in Patients with Acute Coronary Syndrome

作　　者：陈冰雪[1] 王凤飞[2] 曹晓敏[3] 燕颖军[1] 刘莉[1] 叶波[1] 陈盛鹏[1] 

机构地区：[1]白求恩军医学院,石家庄050081 [2]河北医科大学第二医院心内科,石家庄050000 [3]解放军260医院心内科,石家庄050041

出　　处：《白求恩军医学院学报》2003年第3期150-152,共3页Journal of Bethune Military Medical College

摘　　要：目的　探讨急性冠状动脉综合征 (ACS)患者C 反应蛋白 (CRP)的血清学改变及其与ACS产生机制、冠状动脉病变范围和血脂变化的关系。方法　将经冠状动脉造影后诊断为冠心病的 96例患者分为两组。其中ACS组 5 3例 (急性心肌梗死 2 1例 ,不稳定性心绞痛 32例 ) ;非急性冠状动脉综合征 (NACS)患者组 4 3例 (陈旧性心肌梗死 14例 ,稳定性心绞痛 2 9例 )。以 32例有胸痛症状而冠状动脉造影排除冠心病的患者为对照组。分别测定CRP和总胆固醇 (TC)、甘油三酯 (TG)、高密度脂蛋白胆固醇(HDL C)及低密度脂蛋白胆固醇 (LDL C)的浓度 ,并与 32例对照组进行对比研究。结果　ACS组患者血清CRP水平明显高于NACS组 (P<0 .0 5 )和对照组患者 (P<0 .0 1) ,NACS组的CRP水平也显著高于对照组 (P <0 .0 1)。CRP水平的升高与冠状动脉病变累及范围呈正相关性 ,而与血脂水平无关。结论　ACS发生时有炎症表现 ,可能为冠状动脉粥样硬化斑块不稳定的因素之一 ,CRP水平的升高不仅与动脉粥样硬化的形成和发展有关 。Objective To study the changes of C reactive protein (CRP) in patients with acute coronary syndrome (ACS),range of coronary stenosis and lipid level in the patients with ACS. Methods 96 patients with coronary heart disease (CHD) approved by coronary artery angiography (CAG) were divided into 2 groups.One group was 53 patients with ACS including 21 patients with acute myocardial infarction (AMI) and 32 patients with unstable angina pectoris.The another group was definded as 43 patients with non acute coronary syndrome (NACS) including 14 patients with old myocardial infarction and 29 patients with stable angina pectoris.CRP,TC,TG,HDL C and LDL C were tested in all patients and compared with 32 control group. Results Level of CRP in ACS group was significantly higher than that in NACS (P<0.05) and control (P<0.01) groups.CRP in NACS group was also significantly higher than that in control group (P<0.01).The levels of CRP in both ACS and NACS groups were positive correlated with range of coronary stenosis,but not correlated with lipid levels in each subgroups. Conclusion Occurrence of ACS is related to inflammation,which may be one of the factors of bringing about plaque unstable.Increased CRP may also affect the formation of atherosclerosis and related with the range of coronary stenosis.

关 键 词：C-反应蛋白 急性冠状动脉综合征 冠心病 

分 类 号：R541.4[医药卫生—心血管疾病]