不同剂量西地那非治疗新生儿肺动脉高压的疗效  

The effect of different doses of sildenafil in the treatment of neonatal pulmonary hypertension

作　　者：李志标[1] 

机构地区：[1]中山大学附属第三医院,广东汕头440100

出　　处：《世界最新医学信息文摘》2015年第65期73-74,共2页World Latest Medicine Information Electronic Version

摘　　要：目的探讨不同剂量的西地那非(SIL)对于治疗新生儿持续性肺动脉高压(PPHN)的临床疗效。方法选择2010年12月至2014年06月在我院就诊的72例PPHN患儿,按照随机原则将72例患儿平均分为三组,其中A组0.6mg/kg SIL,B组1.2mg/kg SIL,C组2.0mg/kg SIL,对比各组患儿治疗前后的肺动脉压力(SPAP)和脉搏氧饱和度数值变化。结果各组治疗后较之前均有明显改善,同时剂量越大,改善程度越明显,组间有统计学差异(P<0.05)。结论 SIL在改善PPHN患儿肺动脉压力及脉搏氧饱和度方面有显著效果,且治疗效果与药物浓度有一定关系。ObjectiveTo explore the clinical efifcacy of different dosage of SIL in PPHN.Method72 PPHN children treated from December 2010 to June 2014 in our hospital were selected and were randomly and equally divided into three groups. Group A adopted 0.6mg/kg SIL; Group B adopted 1.2mg/kg SIL while Group C adopted 2.0mg/kg SIL. The value of SPAP and pulse oxygen saturation of three groups before and after treatment was compared.ResultThe value of SPAP and pulse oxygen saturation of three groups was higher than before; with the increasing dosage of SIL, the improvement was better (P<0.05).ConclusionFor PPHN children, SIL has an obvious effect in the improvement of SPAP and pulse oxygen saturation. The treatment effect has a certain correlation with drug concentration.

关 键 词：西地那非 新生儿 肺动脉高压 

分 类 号：R722.1[医药卫生—儿科]