嗜酸性粒细胞在抗过敏反应中的应用研究  

Study on the Application of Eosinophils in Anti-allergic Reaction

作　　者：梁铎耀 李博琨 LIANG Duo-yao;LI Bo-kun(Taiyuan foreign language school,Taiyuan Shanxi)

机构地区：[1]太原市外国语学校

出　　处：《世界最新医学信息文摘》2018年第72期141-142,共2页World Latest Medicine Information Electronic Version

摘　　要：本文中以嗜酸性粒细胞作为原材料制备药物,或从灭活寄生虫中提取趋化因子,增殖人体内的嗜酸性粒细胞,治疗过敏反应。采用方法:提取灭活寄生虫体内可使嗜酸性粒细胞增殖的趋化因子ECFP。将ECFP制作为凝胶以治疗皮肤过敏,或制作为注射液治疗急性过敏反应。利用动物组织培养技术在体外增殖从人或哺乳动物外周血中分离出的嗜酸性粒细胞。利用细胞破碎技术提取嗜酸性粒细胞内的组胺酶,制备组胺酶类药物。将药物与嗜碱性粒细胞混合培养以检测药物活性。研究后发现利用嗜酸性粒细胞生产的药物可有效治疗人体的过敏反应。部分药物相比于传统药物更具有治疗的针对性,可降低治疗时对人体的不良影响。In this paper, eosinophils are used as raw materials to prepare drugs, or chemokines are extracted from inactivated parasites to proliferate human eosinophils and treat allergic reactions. Methods: ECFP, a chemokine which can proliferate eosinophils in inactivated parasites, was extracted. ECFP was made into gel to treat skin allergy or injection to treat acute allergic reaction. Eosinophils isolated from human or mammalian peripheral blood were proliferated in vitro by animal tissue culture technique. Histamine enzymes were extracted from eosinophils by cell disruption technique to prepare histaminase drugs. Mixed drugs and basophils were cultured to detect drug activity. The study found that the use of eosinophils produced drugs can be effective in the treatment of human allergies. Some drugs are more targeted than traditional drugs, which can reduce the adverse effects on the human body.

关 键 词：过敏反应 嗜酸性粒细胞 寄生虫 提取嗜酸性粒细胞 动物组织培养技术 组胺酶 

分 类 号：R593.1[医药卫生—内科学]