肺结核患者血清中IAP和T淋巴细胞亚群关系的研究  

Study on the correlation between serum immunosuppres sive acidic proteins and Tlymphocyte subsets of patients with pulmonary tube rculosis

作　　者：费晓峰[1] 吴建鸿[1] 

机构地区：[1]苏州市第五人民医院,苏州215007

出　　处：《中国防痨杂志》2003年第6期388-390,共3页Chinese Journal of Antituberculosis

摘　　要：目的　探讨肺结核患者血清中免疫抑制酸性蛋白 (IAP)水平及自身T淋巴细胞亚群间的变化与结核病发生发展间关系。方法　采用琼脂扩散法和碱性磷酸酶抗碱性磷酸酶 (APAAP)法分别测定 1 2 2例肺结核患者血清中IAP和T淋巴细胞亚群变化。结果　肺结核病患者血清中IAP水平明显增高 ,CD3 、CD4、CD4/CD8明显降低 ,与对照组比较统计学处理均有显著差异 (P <0 .0 5) ;进展期较稳定期和好转期变化更明显 (P <0 .0 5)。IAP水平与CD3 、CD4、CD4/CD8相关分析呈明显负相关 (P <0 .0 5) ,与CD8呈明显正相关 (P <0 .0 5)。Objective To study the correlation between serum immunosuppressive acidic proteins (IAP) and T lymphocyte subsets in patie nts with pulmonary tuberculosis(TB).Methods The levels of IAP were detected by agar diffusion assay, and T lymphocyte subsets detected by the technique of alkaline phosphatase and anti-alkaline pho sphatase (APAAP) in 122 patients suffered from pulmonary TB and 45 healthy indiv iduals.Results The level of IAP was higher,and the expression of CD 3,CD 4 and the ratio of CD 4/CD 8 were lower in patien t group and both of those two indicators showed a siginificant difference with t hat control group(P<0.05).The changes of them were more obvious in progressi ve stage than that in stable and improving stages, respectively (P<0.05).The re was a negative correlation between IAP level and the expression of CD 3,CD 4 and the ratio of CD 4/CD 8(P<0.05).There was a positive correlation betw een CD 8 expression (P<0.05).Conclusion The results indicate the change of IAP level and T lymphocyte subset may be rela ted with the severity and prognosis of pulmonary TB patient.

关 键 词：肺结核 血清 IAP T淋巴细胞亚群 

分 类 号：R521[医药卫生—内科学]