亚低温方法抗重度颅脑损伤作用的临床研究  

Clinical study on the effect of mild hypothermia against severe craniocerebral injury

作　　者：闫晓明[1] 刘庆波 罗毅男[1] 陈儇[1] 洪新宇[1] 

机构地区：[1]吉林大学第一临床医院神经外科,吉林长春130021 [2]长春市第二人民医院外科

出　　处：《中国实验诊断学》2003年第6期534-535,共2页Chinese Journal of Laboratory Diagnosis

摘　　要：目的　探讨亚低温方法抗重度颅脑损伤的作用机制。方法　对 34例重度颅脑损伤患者 (Gcs≤ 8)随机分为亚低温治疗组 (16例 )和常温治疗组 (18例 )。分别测定 2 4h内血中丙二醛 (MDA)和脑脊液中 β 内啡呔 (β Ep)含量。结果　亚低温组患者伤后 2 4h血清中MDA含量及脑脊液中 β Ep含量均明显低于常温组 ,差异具有显著性 (P <0 .0 1)。结论　亚低温方法可以使重度颅脑损伤患者急性期内有害物质生成减少 ,从而减轻了脑损伤 ,是临床救治重度颅脑损伤的一种重要方法。Objective To determine the effect mechanism of mild hypothermia against severe craniocereBral injury.Methods 34 patients(Gcs≤8) with severe craniocereBral injury were divided into mild hypothermia group(16 cases) and northermia group(18 cases) randomly. The MDA in the serum and β-Ep in the cereBrospinalfluid wre detected with 24 hours.Results The MDA andβ-Ep in mild hypothermia group are evidently lower than northermia group, and has significant difference (P<0.01).Conclusion The mild hypothermia cure can inhibit the production of harmful substance and decrease Brain injury. It is important therapy to severe craniocerebral injury.

关 键 词：亚低温方法 颅脑损伤 临床研究 丙二醛 Β-内啡呔 

分 类 号：R651.15[医药卫生—外科学]