儿童肾脏病患者血清白介素-2、白介素-6和胰岛素样生长因子-Ⅱ检测及其临床意义  

Clinical Application of Determination of Serum Interleukin-2,Interleukin-6 and Insulin-like Growth Factor-Ⅱ in Children with Renal Disease

作　　者：许瑞吉[1] 王国洪[1] 张中书[1] 施益群[1] 赵技文[1] 

机构地区：[1]南京军区南京总医院核医学科,江苏南京210002

出　　处：《标记免疫分析与临床》2003年第4期213-215,共3页Labeled Immunoassays and Clinical Medicine

摘　　要：为观察儿童肾脏病患者血清白介素 - 2 (IL - 2 )、白介素 - 6 (IL - 6 )、胰岛素样生长因子 -Ⅱ (IGF -Ⅱ )的含量 ,探讨细胞因子与肾脏病的关系 ,采用RIA法检测了不同肾脏病儿童患者血清IL - 2、IL - 6、IGF -Ⅱ的水平。结果显示 ,正常儿童血清IL - 2含量为 1 .6 0± 0 .32 μg/L、IL - 6为 37.0± 6 .0ng/L、IGF -Ⅱ为 0 .30±0 .1 5μg/L。正常男女性儿童之间血清三个细胞因子含量无显著性差异 (P >0 .0 5 )。正常儿童与成年人之间三个细胞因子有显著性差异 (P <0 .0 1 )。慢性肾小球肾炎血清IL - 2含量为 1 .96± 0 .4 4 μg/L、IL - 6为 5 4 .9± 2 0 .9ng/L、IGF -Ⅱ为 0 .5 2± 0 .1 5 μg/L ;急性肾炎血清IL - 2含量为 1 .92± 0 .4 7μg/L、IL - 6为 76 .3± 36 .2ng/L、IGF -Ⅱ为 0 .6 2± 0 .2 2 μg/L ;紫癜性肾炎血清IL - 2含量为 1 .91± 0 .33μg/L、IL - 6为 5 5 .5± 1 5 .1ng/L、IGF -Ⅱ为 0 .5 0± 0 .1 9μg/L ;肾病血清IL - 2含量为 1 .96± 0 .6 5 μg/L、IL - 6为 5 6 .2± 2 8.4ng/L、IGF -Ⅱ为 0 .5 9±0 .2 8μg/L ;不同肾脏病儿童三个细胞因子与正常人相比有显著差异 (P <0 .0 1 )。提示 :不同肾脏病儿童血清IL- 2、IL - 6、IGF -Ⅱ含量升高表明 ,这三个细胞因子均积极参与?In order to study the relationship between cytokine and renal disease, the levels of serum IL-2, IL-6, and IGF-Ⅱ were detected by radioimmunoassay in children with renal disease. Results showed that there are a significant difference in the serum concentration of IL-2, IL-6,and IGF-Ⅱ between healdren′ and adult. The levels of IL-2, IL-6 and IGF-Ⅱ in children with renal disease were significantly different compared with normal control group. Conclusion: IL-2, IL-6 and IGF-Ⅱ might play an important role in children with renal disease.

关 键 词：肾脏病 白介素-2 白介素-6 胰岛素样生长因子-Ⅱ 放射免疫分析 

分 类 号：R726.9[医药卫生—儿科]