乙型肝炎病毒前S_1抗原检测及其临床意义  

The Clinical Significance of Detection of Serum Pre-S_1 Antigen

作　　者：蒋雪花[1] 黄祝青[1] 韩燚[1] 龚守军[1] 

机构地区：[1]武警上海总队医院传染科,上海201103

出　　处：《标记免疫分析与临床》2003年第4期199-201,共3页Labeled Immunoassays and Clinical Medicine

摘　　要：为探讨检测乙型肝炎病毒前S1 抗原 (Pre -S1 Ag)的临床意义 ,本文对 338例各型乙型肝炎患者进行Pre-S1 Ag检测 ,同时检测HBV标志物和HBV -DNA ,对其阳性率及相互关系进行分析比较。结果表明 :338例患者 ,Pre -S1 Ag阳性检测率为 6 3.0 2 % ,HBeAg阳性检测率为 4 8.5 2 % ,HBV -DNA阳性检测率为 6 8.0 5 %。Pre -S1 Ag阳性与HBV -DNA阳性的符合率为 78.5 6 % ;Pre -S1 Ag与HBeAg阳性的符合率为 81 .1 7% ;Pre -S1 Ag与HBeAg、HBV -DNA具有显著相关性 (P <0 .0 1 ) ,提示Pre -S1 Ag能够较好地反映病毒复制状况 。To study the clinical significance of detection of serum Pre-S 1 Ag, the serum Pre-S 1Ag, HBV-marks and HBV-DNA were detected in 338 patients with hepatitis B.The positive rate and the relationship between them were analyzed and compared. In 338 patients, the positive rate of serum Pre-S 1Ag, HBeAg, HBV-DNA was 63.02%, 48.52%, 68.05% respectively, and the co-positive rate of Pre-S 1 Ag with HBV-DNA, HBeAg was 78.56%, 81.17% respectively.There was a significant correlation between Pre-S 1Ag, HBeAg and HBV-DNA( P <0.01).Serum Pre-S 1Ag could well reflect the reproductive status of hepatitis B virus, and so it could be used as the clinical marker of the reproductive status of hepatitis B virus.

关 键 词：前S1抗原 乙型肝炎病毒 

分 类 号：R446.6[医药卫生—诊断学]