重组人干扰素α_(2a)软膏的动物皮肤试验  

The animal skin test of recombinant human interferonα_(2a) cream

作　　者：石晓丽[1] 张雪梅[1] 王晓宇[1] 

机构地区：[1]长春生物制品研究所,长春130062

出　　处：《生物学杂志》2003年第6期35-36,共2页Journal of Biology

摘　　要：目的 :观察动物皮肤接触重组人干扰素α2a软膏后所产生的刺激反应情况 ,动物完整皮肤及破损皮肤短期内接触重组人干扰素α2a软膏所产生的急性毒性反应以及通过动物皮肤重复接触重组人干扰素α2a软膏后 ,观察机体免疫系统反应在皮肤上表现。方法 :选择家兔和豚鼠为试验动物 ,将干扰素软膏涂在脱毛的动物皮肤上 ,以赋形剂为空白对照 ,2 .4—二硝基氯代苯为阳性致敏物对照。结果 :本品对皮肤的刺激强度〈0 .5 ,即重组人干扰素α2a软膏无刺激性和弱致敏性。结论 :重组人干扰素α2a软膏动物试验中未见皮肤刺激性和过敏性发生 。The stimulus response of the animal skin exposed to recombinant human interferon cream were observed.The partly depilated guinea pigs and rabbits were choosen for test animals.The rIFN cream was smeared repeated on the depilated integral and damaged skin to observe the immunoreactions in skin,and 2,4-dinitrochlorobenze was used as positive conord.The results suggested that rIFN cream was safe and no side reaction.

关 键 词：重组人干扰素Α2A 软膏 刺激性 急性毒性 过敏性 

分 类 号：Q969[生物学—昆虫学]